Complete response to chemotherapy was confirmed as the strongest prognostic factor influencing survival. However, conventional clinicopathologic factors did not predict response, hence, potential prognostic biologic and molecular factors for response must be sought. At present, much effort must be made for the improvement of the complete response rate, which seems to be a requisite to prolong survival.

No abstract

ResumenEl carcinoma renal suele manifestarse clínica-mente de forma tardía, por lo que aproximadamente un tercio de los pacientes presentan metástasis a distancia en el momento del diagnóstico. En estos casos, la supervivencia disminuye drásticamente, situándose en una media de 12 meses. Se han descrito algunos casos de regresión espontánea (RE) en este tumor, que varían desde regresiones completas y duraderas hasta parciales y temporales. La RE se presenta entre el 0,4 y el 4% de los pacientes con carcinoma renal mestastásico (CRM). A pesar de estar descritos muchos factores relacionados con este raro y favorable suceso, no se conoce su verdadero origen y no es, por tanto, un evento predecible. Presentamos un caso de RE tras nefrectomía en un paciente con carcinoma renal, que presentaba metástasis pulmonares confirmadas histológicamente y recidiva local.Palabras clave: Carcinoma Renal. Regresión Espontánea. Nefrectomía. Oncología, 2006; 29 (6):263-273 SummaryThe clinical manifestations of renal cell carcinoma are often late, so that approximately one third of the patients have metastatic disease at the time of diagnosis. In this case, the survival rate diminishes dramatically, with an average survival time of 12 months. However, some cases of spontaneous regression have been reported for this kind of tumor, either complete and permanent or partial and temporary. Spontaneous regression occurs in 0.4-4.0% of the patients with metastatic renal cell carcinoma. Many factors have been proposed as related with this rare but favorable event, but until now the origin remains unknown and no prediction can be made. We present a case of renal cell carcinoma with histologic confirmation of lung metastases and local relapse showing a spontaneous regression after nephrectomy.

No abstract

No abstract