Background: Smoking is associated increase in morbidity and mortality from various diseases. Increasing evidence suggests that chronic smoking adversely affects vascular and hormonal systems. Smoking plays a significant role in the development of atherosclerosis, thrombogenesis and vascular occlusion, which further adversely affects the prognosis of nephropathies. Aim and. Objectives: to estimate and compare the levels of hSCRP and microalbumin levels in smokers and non-smokers. Materials and Methods: Under aseptic precautions random venous blood sample of 2 mL was drawn from ante-cubital vein and collected in red top tube and serum was separated and analysed for high sensitivity C reactive protein (hSCRP). Early morning mid-stream urine was used for urine microalbumin estimation and the same sample was used for urine microscopy to exclude patients with urinary tract infection. Statistical Analysis: All statistical tests was performed using SPSS software. For comparisons of different variables student’s t-test and Chi-square test were be used. Pearson coefficient of correlation was used for assessment of relationship between variables. A p value <0.05 was considered statistically significant.