Optimum plant spacing ensures proper growth and development of crops resulting in maximum crop yield and economic use of land. The objective of this study was to evaluate the effects of different planting spacing on the growth and yield of California Wonder Bell Pepper (Capsicum annuum) on sandy loam soil of The Gambia, from January to May 2018. The design used for this experiment was a Randomized Complete Block Design (RCBD) with four treatments (T1: 50 x 50 cm, T2: 50 x 40 cm, T3: 50 x 30 cm and T4: 50 x 20 cm) and three repetitions and the parameter of plant height, stem girth, number of leaves, fruit length, fruit circumference, individual fruit weight, yield per plant, and yield per hectare. The plant spacing had a significant effect on plant height, stem girth and the number of leaves of the growth parameters, whereas for the yield parameters, individual fruit weight, yield per plant and total biomass yield were found significantly in treatments with the highest plant spacing (50 x 50 cm). In conclusion, wider plant spacing (50 x 50 cm) boosts the plants to develop the maximum number of branches and fruits.