e18290 Background: Detection and prevention of cancer cachexia during oncologic treatment is an important issue in cancer patients care. AIM: To analyze the relation between overall survival and nutritional status assessed both by subjective and objective methods, in a prospective cohort of oncologic patients. Methods: Between 2012-2014 all patients under treatment in the Oncology Unit of Clinica Alemana de Santiago were invited to participate in this study, and follow-up was completed August 2018. Exclusion criteria were terminal phase patients, or those with cognitive deterioration. Apart from recording demographic, clinical and nutritional data, whenever possible, recent computed tomographic images were analyzed through Slice O Matic, at the level of the third lumbar vertebra, for measurement of abdominal fat and muscle area. Muscle Mass Index (MMI) was calculated as muscle area/squared height. The control group was composed by 130 healthy subjects 18-40 years, whose computed tomography images were obtained as part of the trauma protocol. The cutoff for sarcopenia was MMI < -1 SD respect control subjects. In addition, nutritional status was assessed through anthropometric measurements and the Patient Generated Subjective Global Assessment (VGSGP). Results: We included 103 patients, predominant cancer sites were digestive, haematologic and lung; average survival was 33 ± 23 months. The sample was divided in 2 groups (TNM stages 1 and 2 versus 3 and 4). MMI in control subjects was significantly higher than values obtained from 64 oncologic patients with available CT scans, while fat area, specifically visceral, was the opposite. VGSGP scores correlated negatively and significantly with MMI (p < 0.001). According to univariate analysis, survival time was inversely associated with age among male patients ( p = 0.002), cancer stage in both genders p < 0.01), VGSGP (p < 0.01), and positively associated with MMI, only among men (p = 004). Kaplan Meir survival estimates were significant both sarcopenia and cancer stage. According to Cox regression, both sarcopenia and cancer stage were significant predictors of mortality, without any effect of age or sex. Conclusions: Both sarcopenia and cancer stage are predictors of survival during treatment of cancer.
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