Introduction This study examines the frequency, associated factors, and characteristics of healthcare personnel coronavirus disease 2019 (COVID-19) cases in a healthcare department that comprises a tertiary hospital and its associated 12 primary healthcare centers. Methods This study included healthcare personnel that showed symptoms or were in contact with a COVID-19 case patient from March 2 to April 19, 2020. Their evolution and characteristics (age, sex, professional category, type of contact) were recorded. Correlations between the different characteristics and risk of developing COVID-19 and severe COVID-19 were analyzed using chi-square tests. Their magnitudes were quantified with ORs, AORs, and their 95% CIs using a logistic regression model. Results Of the 3,900 healthcare professionals in the department, 1,791 (45.9%) showed symptoms or were part of a contact tracing study. The prevalence of those with symptoms was 20.1% (784/3,900; 95% CI=18.8%, 21.4%), with COVID-19 was 4.0% (156/3,900; 95% CI=3.4%, 4.6%), and with severe COVID-19 was 0.5% (18/3,900; 95% CI=0.2%, 0.7%). The frequency of COVID-19 in symptomatic healthcare personnel with a non-protected exposure was 22.8% (112/491) and 13.7% (40/293) in those with a protected exposure (AOR=2.2, 95% CI=1.2, 3.9). The service in which the healthcare personnel performed their activity was not significantly associated with being diagnosed with COVID-19. A total of 26.3% (10/38) of male healthcare personnel with COVID-19 required hospitalization, compared with 6.8% (8/118) among female healthcare personnel (OR=4.9, 95% CI=1.8, 13.6). Conclusions A surveillance and monitoring program centered around healthcare personnel enables an understanding of the risk factors that lead to COVID-19 among this population. This knowledge allows the refinement of the strategies for disease control and prevention in healthcare personnel during the COVID-19 pandemic.

Objectives To describe breakthrough COVID-19 in patients who needed hospitalization and the factors associated with poor outcomes. Methods A retrospective study on complete (diagnosed two weeks after the second dose of the Pfizer/Moderna/AstraZeneca or first dose of the Janssen vaccine was administered) or partial vaccine scheme (CV or PV) patients hospitalized for COVID-19 between December 27, 2020, and October 17, 2021, was conducted. The main outcomes were all-cause mortality and the need for invasive mechanical ventilation (IMV). The baseline factors associated with the outcomes were analyzed by multiple logistic regression, estimating the odds ratios (OR; 95% CI). Results One hundred and forty-five patients (101 CV) were included. The CV subgroup was mainly composed of elderly males with high comorbidity (Charlson index ≥3, 72%; immunosuppression, 20%), with bilateral pneumonia in 63.4%; limited therapeutic effort (LTE) was agreed upon for 28% of the patients. In the CV subgroup, endotracheal intubation was required in 10.9%, reaching 15.3% when excluding LTE patients; the global mortality was 22.8% and 41.4% in the subgroup with LTE. Although the PV patients were younger and had fewer comorbidities, the main outcomes did not differ significantly between the CV and PV groups. The predictors of poor outcomes were age ≥ 65 years, confusion, ferritin > 500 mg/L, extensive lung infiltrates, and a Charlson index ≥ 3. Conclusions Fully vaccinated patients hospitalized due to breakthrough COVID-19 tend to be elderly, with comorbidities, and have high mortality.

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On behalf of COVID19-ALC research group, Effectiveness of a SARS-CoV-2 infection-prevention model in elective surgery patients, a prospective study: Does Universal Screening Make Sense?.

Objetivo: Estimar la prevalencia de anticuerpos IgG frente a SARS-CoV-2 en profesionales sanitarios (PS) de un Departamento Sanitario (DS). Métodos: Estudio de prevalencia. Se determinó la presencia de anticuerpos IgG frente a SARS-CoV-2 en los PS del DS. La determinación se realizó mediante la técnica de ELISA. El trabajo de campo se realizó del 24/04/2020 al 08/05/2020. Se recogió edad, sexo, estamento (facultativo, enfermería, etc.) y área de trabajo (atención primaria, urgencias, etc.). Se calculó la prevalencia de anticuerpos IgG frente a SARS-CoV-2 con su intervalo de confianza al 95% (IC95%). Para estudiar la asociación entre las características de los PS y la presencia de IgG se utilizó la prueba de la Ji Cuadrado y para cuantificar la magnitud de asociación se calculó la Odds Ratio (IC95%). Resultados: De los 4813 PS del DS participaron 4179 (87,1%). De éstos el 73,3% (3065) eran mujeres y el 26,7% (1114) hombres. La prevalencia global de presencia de anticuerpos IgG frente a SARS-CoV-2 fue del 6,6% (IC95%:5,8%-7,3%). Hubo diferencias estadísticamente significativas según estamento, oscilando del 8,7% (IC95%:6,9%-10,6%) en facultativos a un 3,2% (IC95%:1,0%-8,0%) en otro personal no sanitario. El resto de características no se asociaron de forma significativa a la presencia de anticuerpos frente a SARS-CoV-2. Conclusión: La frecuencia de infección por SARS-CoV-2 en PS es similar a la estimada para la población general en grandes ciudades en España, lo que orienta sobre la efectividad del programa de prevención y control de infecciones dirigido a los profesionales sanitarios en este Departamento Sanitario.