Neuropsychological disturbances in the sense of limb ownership (DSO) provide a unique opportunity to study the neurocognitive basis of the sense of body ownership. Previous small sample studies focused on discrete cortical lesions and modular accounts, which cannot explain the modulations of DSO by multisensory, affective and cognitive manipulations. We tested the novel hypothesis that DSO would be associated not only with discrete cortical lesions, but also with disconnections of frontoparietal and fronto-insular white-matter tracts, supporting functional networks for multisensory integration and salience monitoring. To overcome the aforementioned methodological limitations, we drew on an advanced, probabilistic lesion-analysis and Bayesian statistics approach and tested this hypothesis in 49 right-hemisphere patients. Our results reveal that, as predicted, DSO is associated with lesions and disconnections of a fronto-insular-parietal network, suggesting that the sense of body ownership involves the convergence between bottom-up processes of multisensory integration and top-down control and monitoring of sensory salience.