Precisely controlled organic one-dimensional (1D) and two-dimensional (2D) materials with unique optoelectronic properties have attracted wide interests. By the introduction of chlorine into the poly(p-phenylenevinylene) (PPV) core, we produced a series of 1D rod-like micelles, whose sizes were controlled by the concentrations of solutions, using self-assembly (SA) of conjugated copolymers (PPV−Cl 20% ) 10 -b-P2VP 20 . The transformation from 1D rod-like micelles to 2D uniform diamondlike micelles was achieved by the thermally induced nucleation SA. The sizes of the 2D diamond-like micelles could be tuned by the annealing temperature and the ratio of unimer to seed. It is demonstrated that the morphology transformation from rod-like micelles to diamond-like micelles was based on energetics including thermodynamic and kinetic points.

Here we present the intracellular delivery of mRNA using polyhydrazones prepared in situ under physiological conditions, demonstrating the versatility and adaptability of this technology to more sensitive and therapeutically relevant nucleic acids.

The morphological transformation from microspheres to helical supramolecular nanofibers with controllable handedness is achieved by the introduction of molecular chirality based on amino acid derivatives (TDAP), and the chirality of the supramolecular architectures that are achieved is nullified through the coassembly of the equivalent TDAP enantiomers. The molecular detection of achiral melamine based on the R‐TDAP‐COOH supramolecular system is achieved by the appearance of helicity and inversion.

The design of a hemofiltration method that minimizes the side effects produced by accumulation of Pt-based drugs such as cisplatin represents an important technology for cancer treatment. This work establishes the foundation for the development of an efficient platform for the electrochemical hemofiltration and simultaneous sensing of anti-tumour drugs, such as cisplatin and carboplatin, from physiological medium. The electrochemical filtration system is based on a gold surface-modified electrode using tris(carboxyethyl)phosphine (TCEP) ligands as scavengers of the Pt-based drugs complexes. The platinum-phosphine interaction is shown to be more time efficient, as compared to naturally occurring formation of a glutathione-platinum adduct and displayed a highly cooperative nature of binding. Altogether, we demonstrate that the presence of ligands capable of binding to Pt results in a differential spectroscopic and electrochemical response, and the potential to absorb and monitor the concentration of Pt salts in complex aqueous media.

An amino acid derivative, thiophene (TDAV), as new building blocks for 2D supramolecular assembly is designed. Various square and rectangular microsheets are achieved and the aspect ratios are precisely regulated by controlling the polarity of cosolvent or water content. By the introduction of chirality, the novel microsaw is also achieved. It provides a new approach to prepare various kinds of unique supramolecular 2D materials with controllable shapes and sizes for future biological applications.