We compared serum cortisol, ACTH and plasma beta-endorphin in 21 Post-Traumatic Stress Disorder patients and 20 controls. Although we found no important disturbance in diurnal rhythms, the PTSD patients had significantly higher A.M. serum cortisols compared with controls. Both A.M. and P.M. plasma beta-endorphins in PTSD patients were significantly lower compared with controls. These data suggest that plasma beta-endorphin may be a marker for PTSD and that chronic endogenous opioid depletion may play a role in the pathogenesis and perpetuation of this disorder.

PTSD symptoms may have been common during and after World War II. At that time avoidance was not considered a symptom of disorder. Intrusive and arousal symptoms may be the core symptoms of PTSD and avoidance symptoms need to be reconsidered.

PTSD symptoms were probably common during and after World War II. The findings have implications for the management of PTSD generally and the treatment of ageing WWII veterans in particular.