Background: Peripheral neuropathy is a common condition which can have a significant impact on quality of life. It occurs as a component of several common and rare diseases or can be idiopathic and can present with various symptoms.Aims and Objectives: This study is aimed at evaluating the effectiveness and safety of the fixed dose combination of vitamin B1, B6 and B12in mild to moderate peripheral neuropathy of various etiologies in the Indonesian population.Materials and Methods: This was a prospective, open label, multi-center, single arm observational study (Indonesian Clinical Trial Registry No: INA-KPA0DYA). A total of 411 subjects with mild to moderate peripheral neuropathy of various etiologies, who met the eligibility criteria, were included in the study. A subject was considered to have “completed” the study if the study procedures, up to Visit 3 (one month of treatment) were accomplished. Procedural results and 12-week clinical outcomes are reported.Results: Treatment with combination of vitamin B1, B6 and B12 in subjects with symptoms of PN showed significant improvement in overall Total Symptom Score (TSS), within 14 days. The treatment also successfully reduced individual components of TSS from baseline to Visit 5. A significant percentage reduction was also observed for all the Visual Analogue Scale (VAS) parameters at the end of 12 weeks, while the Quality of Life (QoL) scores increased from baseline to the end of treatment.Conclusions: The fixed dose combination of vitamin B1, B6 and B12 was effective and welltolerated in subjects with mild to moderate peripheral neuropathy, of various etiologies.Asian Journal of Medical Sciences Vol.9(1) 2018 32-40

Peripheral neuropathy (PN) is the most common disorder of the peripheral nervous system in adults, and its prevalence increases with age. Because PN is often poorly documented and strongly underdiagnosed, estimating its prevalence in the general population is difficult. Only few epidemiological studies on the prevalence of PN in the general population are available, mostly from industrialized countries. Especially in developing countries, figures from different sources vary considerably. Available data often focus on certain etiological subgroups-particularly diabetics-or on neuropathic pain (NeP), which contributes to this variation. More epidemiological prevalence studies from the general population are required to gain a better picture on sizes of patient groups and cause patterns. To provide an overview of current prevalence data, we performed a selective literature search in PubMed, Cochrane and Google Scholar and used relevant examples along with comprehensive reviews covering the past 15+ years identified through the use of the authors' own files. These data indicate that PN is frequent and often undiagnosed for a long time.Although diabetes is the number one cause of PN worldwide, there are various causes beyond, making it hard for physicians to gain a clear patient picture and recognize symptoms. Most clinical studies also focus on diabetic PN treatment only; thus, data comparing the treatment of PN of several etiologies are rare, which contributes to the lack of awareness of PN causes. In order to demonstrate that different PN subgroups can benefit from treatment with B vitamins progressively over time-regardless of underlying PN causes, we also present some subgroup results of a recent non-interventional study (Neurobion non-interventional; NENOIN) herein. The NENOIN study showed that treating PN of different etiologies including idiopathic neuropathy is possible with a fixed dose of neurotropic B vitamins. Therefore, we conclude that this is an effective treatment option for different PN subgroups from which even patients with unknown PN causes can benefit.

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Low back pain is a very common health problem and can affect the quality of life. Pain that arises in low back pain can be either nociceptive pain or neuropathic pain. This literature review discusses the neuropathic pain component of low back pain.  This review uses a narrative review method. The articles were obtained from keyword searches in the Science Direct, PubMed, and ProQuest databases with a publication range of 2011-2021 in Indonesian or English, and research on the components of neuropathic pain in low back pain. Of the eight articles included in this literature review, the prevalence of neuropathic pain in low back pain was 2.8% - 65.3%. Neuropathic pain can be ruled out using LANSS, DN4, and PDQ. Low back pain with neuropathic pain had symptoms of burning (34.58% - 82.9%), pinpricks (31.77% - 78%), tingling (32.71% - 84.8%), numbness (42.05% - 97%), electric shock (38.97% - 78%), itching (16.82% - 42.4%), cold sensation (12.15% - 48.5%), allodynia (19.62% - 85.4%), 61% hyperalgesia, 14.6% autonomic dysfunction, 100% had dysesthesia, and 100% experienced a decrease in tenderness/prickling. Radicular low back pain is often caused by L5 or S1 root compression and rarely L4. Neuropathic low back pain can be based on an assessment of the symptom profile. Associated risk factors are older age, being a female, greater anthropometric status, the habit of drinking alcohol, smoking, and history of previous lumbar, abdominal or pelvic surgery

Low back pain (LBP) is the most common complaint of low back pain. One of the treatments that can be done is non-pharmacological therapy, namely therapy IR and low level laser therapy (LLLT). Both have similarities in electromagnetic radiation hyperthermia, and serve to reduce pain severity, reduce disability in low back pain patients. The aim of this literature review is to compare the effectiveness of IR and LLLT in reducing pain in low back pain patients. The writing was done by analyzing the literature from several electronic medical journal databases, namely: PubMed-NCBI, ProQuest, Science Direct and Google Scholar. The criteria for inclusion of articles are articles in English and Indonesian in research published in 2011–2021. There are 5 articles used in this literature review. The results of the review found that IR and LLLT were equally effective in reducing pain in low back pain patients. Three out of five IR articles showed more effective results in reducing low back pain. Two of the five articles of LLLT showed more effective results in reducing low back pain, that IR and LLLT have the same effectiveness in reducing low back pain