Highlights d Mitochondrial myopathy patients have NAD + deficiency in muscle and blood d Niacin is an efficient NAD + booster in humans d Niacin improves muscle strength and fatty liver in mitochondrial myopathy d Niacin boosts muscle mitochondrial biogenesis and respiratory chain activity in humans

A study was designed to investigate whether asthma, when carefully managed, is associated with an increased risk of complications in connection with pregnancy. One hundred and eighty one asthmatic women were monitored during 198 pregnancies. Antiasthmatic treatment consisted of inhaled f2 adrenergic drugs, beclomethasone, sodium cromoglycate, oral theophylline, and systemic corticosteroids as needed. Postpartum information on asthmatic symptoms and infant feeding was collected by means of a questionnaire. A control group of 198 non-asthmatic pregnant women was matched for age and parity. Atopic women had less severe asthma than non-atopic women. During pregnancy 40% of the patients were managed with the same antiasthmatic medication as before pregnancy; 18% needed less and 42% more medication. Pre-eclampsia occurred more often in asthmatic than control subjects, especially in patients with severe asthma. Hypoglycaemia occurred more often in infants of mothers with severe asthma than in infants of mothers with less severe disease. Theophylline medication at term did not influence labour or delivery. Asthma caused no emergencies during labour. Among the asthmatic subjects 28% ofbabies were delivered by caesarean section compared with 17% in the control group. There was no difference between asthmatic and control subjects with regard to length of gestation, birth weight, incidence of perinatal deaths, low Apgar scores, neonatal respiratory difficulties, hyperbilirubinaemia, or malformations. It is concluded that severe asthma or systemic corticosteroid treatment (or both) during pregnancy seems to increase the incidence of mild pre-eclampsia in the mother and hypoglycaemia in the infant. The findings suggest that careful supervision of asthma during pregnancy and labour by obstetricians and chest physicians working in close collaboration should prevent most of the serious obstetric and neonatal complications of asthma in pregnancy reported by previous authors.Gluck and Gluck,' after a prospective study, reported that symptoms of asthma worsened during pregnancy in 43% of patients and improved in 14%. Exacerbation of asthmatic symptoms usually occurs during the last trimester,' although women with extrinsic (atopic) asthma tend to have fewer symptoms during pregnancy than patients with intrinsic asthma.2 Bronchial asthma in the mother has been associated with increased perinatal morbidity and mortality,34 and also with increased morbidity during infancy.3 Obstetric complications have been observed more

Crackles are short interrupted breath sounds usually associated with pulmonary disorders. According to present opinion, a crackle is generated when an abnormally closed airway opens during inspiration or closes at the end of expiration. The timing of crackles in breathing cycles can be assessed with phonopneumography, their duration with time-expanded waveform analysis, and their pitch with analysis of frequency spectra. The timing, pitch and waveform of crackles are different in pulmonary disorders reflecting different pulmonary pathophysiology. This review deals with the genesis, auscultation, recording and analysis of crackles, with an emphasis on modern signal-processing methods.

Background: Onset of allergic asthma has a strong association with childhood but only a few studies have analyzed incidence of asthma from childhood to late adulthood in relation to allergy. The purpose of the study was to assess age-specific incidence of allergic and non-allergic asthma. Methods: Questionnaires were sent to 8000 randomly selected recipients aged 20-69 years in Finland in 2016. The response rate was 52.3% (n = 4173). The questionnaire included questions on e.g. atopic status, asthma and age at asthma diagnosis. Asthma was classified allergic if also a physician-diagnosed allergic rhinitis was reported. Results: The prevalence of physician-diagnosed asthma and allergic rhinitis were 11.2 and 17.8%, respectively. Of the 445 responders with physician-diagnosed asthma, 52% were classified as allergic and 48% as non-allergic. Median ages at diagnosis of allergic and non-allergic asthma were 19 and 35 years, respectively. Among subjects with asthma diagnosis at ages 0