The morphologic abnormality of cattle and goat livers (collected from slaughterhouses in Mymensinghcity of Bangladesh) were investigated in the present study. The livers of slaughtered cattle (n = 14) and goat (n = 20) were examined by gross visualization, palpation and incision as well as histopathology. The total liver lesion in cattle was 71.4% and in goat was 75%. Grossly, various pathological changes, mainly thickened, rough capsule which was whitish in color, necrotic foci, thickened bile ducts with matured flukes, fibrosis were seen. Histopathologically, necrosis, degenerative changes of hepatocytes, dilated sinusoids, inflammatory infiltrates, granuloma, bile duct hyperplasia, periportal and periductal fibrosis were found in cattle and goat livers. Extensive fibrosis was seen portal areas of liver by Goldner’s trichrome staining. Migratory tracts and immature flukes were seen in intrahepatic bile ducts. Most common cause of liver lesions found in the present study was Fascioliasis in both cattle and goat. It could be concluded that the major gross and microscopic alterationsin the livers of cattle and goat due to Fasciola giganticainfectionreflected tissue damage, which can lead to substantial financial losses in animals and great health problems in human. Therefore, special care and attention are required to ensure that seriously damaged livers of food animals are not passed on for human consumption, and extensive monitoring and epidemiological surveys are necessary to cope this adverse situation