Monitoring renal allograft function after transplantation is key for the early detection of allograft impairment, which in turn can contribute to preventing the loss of the allograft. Multiparametric renal MRI (mpMRI) is a promising noninvasive technique to assess and characterize renal physiopathology; however, few studies have employed mpMRI in renal allografts with stable function (maintained function over a long time period). The purposes of the current study were to evaluate the reproducibility of mpMRI in transplant patients and to characterize normal values of the measured parameters, and to estimate the labeling efficiency of Pseudo‐Continuous Arterial Spin Labeling (PCASL) in the infrarenal aorta using numerical simulations considering experimental measurements of aortic blood flow profiles. The subjects were 20 transplant patients with stable kidney function, maintained over 1 year. The MRI protocol consisted of PCASL, intravoxel incoherent motion, and T1 inversion recovery. Phase contrast was used to measure aortic blood flow. Renal blood flow (RBF), diffusion coefficient (D), pseudo‐diffusion coefficient (D*), flowing fraction ( f), and T1 maps were calculated and mean values were measured in the cortex and medulla. The labeling efficiency of PCASL was estimated from simulation of Bloch equations. Reproducibility was assessed with the within‐subject coefficient of variation, intraclass correlation coefficient, and Bland‐Altman analysis. Correlations were evaluated using the Pearson correlation coefficient. The significance level was p less than 0.05. Cortical reproducibility was very good for T1, D, and RBF, moderate for f, and low for D*, while medullary reproducibility was good for T1 and D. Significant correlations in the cortex between RBF and f (r = 0.66), RBF and eGFR (r = 0.64), and D* and eGFR (r = −0.57) were found. Normal values of the measured parameters employing the mpMRI protocol in kidney transplant patients with stable function were characterized and the results showed good reproducibility of the techniques.
Purpose: to evaluate the prognostic potential of a multiparametric renal MRI protocol (perfusion, diffusion and T1) for the assessment of the allograft in the very early stages after transplantation. Methods: 18 transplanted patients were imaged 6 days after the transplantation with ASL, IVIM and T1 mapping sequences. 2 groups were made depending on the allograft evolution (group A: no adverse events and group B: any adverse event). Results: eGFR, album-creatinine ratio and cortical and medullary RBF were significantly higher in allografts of group A than in group B. Significant correlations between eGFR and RBF were found.
Introduction and Aims:The bioelectrical impedance analysis (BIA) is a noninvasive and painless technique is easy to perform , which is used for determining body composition . Can offer information about membrane cell integrity, volemia and clinical status. We evaluate use of BIA and two bioelectrical parameters (Phase angle -PA-, and extracelular/intracelular watter ratio -ECW/ICW-) as a prognostic markers in acute kidney injury (AKI) . Methods: We include a cohort of 83 patients (médium age 64 years SD 1.8, and male 72.3 % with AKI, and BIA. We evaluate clinical prognostic index (individual severity index
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