This paper presents a diagnostic to detect that the safety and health signals comply was made with the requirements of NOM-026-STPS-2008 within a manufacturing laboratory, the study was carried out in concordance with the provisions of the afore mentioned regulations pertaining to the Secretaría del Trabajo y Previsión Social, which is the government entity in charge of carrying out the corresponding compliance inspections in Mexico in terms of colors and signs of safety and hygiene which a work center is operating. This study was made based on the measurements of the architectural plan of the place to the location of the machinery and tools. Was made to the location of safety and hygiene signs within the place, the identification of the existence of emergency facilities, of risks and hazards within the work area, the detection of the use of signage of obligation and prohibition that helps to control the risks. The most important limitation for the arrangement of the signals is the inadequate distribution in the work area, however, the study had to adapt to this circumstance. With the aforementioned, a proposal is made to rearrange the signage that is located in incorrect points, as well as mentioning the safety signals that are needed in the points identified within the site with their technical specifications. Finally, an area of opportunity is detected to improve the working conditions manufacturing laboratory and thereby contribute to avoid accidents and occupational diseases therefore preventive and corrective measures are applied with the proper use of signage in an area of work.