One of the standards in medicine service compiled by the National Sharia Council of Indonesian Ulema Council (DSN MUI) and Indonesian Islamic Health Effort Council (MUKISI) is a drug formulary that does not contain haram substances. In addition, the number of medicines with a halal label in Indonesia is still limited. Even though there is law no. 33 of 2014, which requires a halal certification for all products, including medicines sold in Indonesia. The pharmaceutical industry has not fully supported this issue and still faces many challenges in making this happen. The purpose of this study is to determine the implementation of the halal medicine selection process in Nur Hidayah Hospital Yogyakarta. It is qualitative research with a case study approach. Data were collected using interview, observation, and documentation techniques. The study reveals four themes in the halal medicine implementation selection process at Nur Hidayah Hospital. Those are medicine screening based on sharia principles, the limitation of medicine with the halal label, the use of haram medicine based on doctor-patient agreement using sharia informed consent, and producer statement as a middle ground.