The coordinated assurance of interrelated critical properties, such as system safety and cyber-security, is one of the toughest challenges in critical systems engineering. In this chapter, we summarise approaches to the coordinated assurance of safety and security. Then, we highlight the state of the art and recent challenges in human-robot collaboration in manufacturing both from a safety and security perspective. We conclude with a list of procedural and technological issues to be tackled in the coordinated assurance of collaborative industrial robots.3 Throughout this chapter we refer to cobots as robots, including their software and operational infrastructure, specifically designed for human-robot collaboration, although we accept that traditional robots may be used in collaborative ways when augmented with sufficient control and sensory systems.