Rhino cerebral orbital mucormycosis is an aggressively spreading fungal infection caused by filamentous fungi of the Mucoraceae family and is found to be more prone in patients with comorbidities that include: uncontrolled diabetes mellitus, immune-suppressed patients, iron and aluminum overload, chronic steroid therapy, severe trauma, and protein-energy malnutrition. A 51year old male patient was admitted to the hospital with a complaint of headache and intermittent fever. The patient had no history of diabetes or denovo hypertension. Based on the analysis of histopathological and radiological investigations, the patient was diagnosed with mucormycosis. The patient furthermore underwent an endoscopic surgical debridement followed by standard treatment including antifungal antibiotic(amphotericin-B) and azole antifungals (posaconazole) along with symptomatic treatment. Though the patient was given all possible therapy available, no improvement was seen in the patient's condition (poor prognosis).

Management of coronavirus disease 2019 (COVID-19) infection is based on limited data and keeps changing rapidly as new clinical data emerge. Remdesivir has shown to reduce duration of hospital stay and has been approved for treatment. In RECOVERY trial, corticosteroids lowered 28-day mortality in patients requiring oxygen supplementation or mechanical ventilation. Convalescent plasma did not live up to its initial promise and is not the standard of care for treatment at present. There’s not enough evidence for use of Hydroxychloroquine, Interleukin-6 inhibitors and many other investigational drugs. Bamlanivimab, casirivimab- imdevimab combo, all monoclonal antibodies, have recently been approved for use in mild to moderate COVIID-19, when there’s a high risk of progression to severe disease. Treatment of COVID-19 depends on stage and severity of disease. Antiviral medications are likely to be most effective when used early. Later in the disease, anti-inflammatory medications, anticoagulants and immunomodulators may be more effective. The world is waiting and hoping for a safe and effective vaccine which can put an end to this worldwide pandemic. Keywords: COVID-19; treatment; coronavirus disease; remdesivir; favipravir; hydroxychloroquine; COVID antibody therapies