We report a library consisting of some novel Hantzsch dihydropyridines and Biginelli dihydropyrimidines of biological interest as well as their synthesis and analysis. The important steps in the synthetic part were found to be Hantzsch and Biginelli multicomponent reactions. The synthesized compounds were screened for their in vitro antibacterial activity against two gram-positive bacteria: Staphylococcus aureus and Bacillus subtilis. The title compounds did not exhibit potential antibacterial activity. Furthermore, compounds were subjected to in vitro cytotoxicity against Vero cells. Compounds exhibited weak, moderate, or high cytotoxicity. Compounds 4a, 4b, 4c, 4f, 4g, 4h, 4i, 7i, 7l, 7m, and 7r exhibited potential cytotoxicity. CoMFA study has resulted in the identification of structural features contributing toward their cytotoxicity.

magnified imageA solventless parallel synthesis of some novel, N‐substituted dihydropyridines by the application of microwaves is reported. The synthetic methodology adopted to synthesize the titled compounds and their antioxidant activity is described. J. Heterocyclic Chem., 46, 336 (2009).

Pyridine derivatives R 0380 Facile, Microwave-Assisted Parallel Syntheses of N-Substituted 1,4-Dihydropyridines of Biological Interest. -6 Title compounds of type (V) are prepared. Compounds (Vb) and (Vc) are found to possess significant antioxidant activities [for intermediates (III) no yields given]. -(KUMAR*, B. R. P.; MASIH, P.; LUKOSE, C. R.; ABRAHAM, N.; PRIYA, D.; XAVIER, R. M.; SAJI, K.; ADHIKARY, L.; J.