Survivors of critical illness have long-term morbidity resulting in physical, emotional, and cognitive dysfunction. 1,2 Early mobilization improves functional outcomes and is essential to quality critical care. [3][4][5][6] Early mobilization is feasible and safe for critically ill patients, including those receiving mechanical ventilation and extracorporeal membranous oxygenation (ECMO).

Introduction: the participation of Cyclooxygenase-2 (COX-2) and Osteopontin has been postulated in the development of colon cancer, which play an important role in the progression and could be biomarkers for its prognosis, but their role remains controversial. Objective: to determine and to compare the expression of Osteopontin and COX-2 in non-tumor colonic mucosa, colonic adenomas and colon adenocarcinoma, in relation to the cell proliferation index. Methods: the immunohistochemical expression of COX-2, Osteopontin and Ki-67 in formalin fixed paraffin embedded tissue of non-tumor colonic mucosa, colonic adenomas and colon adenocarcinoma were determined and compared. Results: were included 65 cases: 19 of non-tumor colonic mucosa, 13 colonic adenomas and 33 colon adenocarcinomas. There was increased expression of Ki-67 in dysplastic and tumor cells. There was positive expression for COX-2 in adenomas (30.7%) and adenocarcinomas (27.3%), without significant difference between non- tumor colonic mucosa, adenomas and adenocarcinoma (p = 0.888). Osteopontin showed more frequent positivity in adenocarcinomas (72.7%) and adenomas (84.6%) than in non-tumor mucosa (10.5%), (p = <0.0001), without significant differences in its expression between subtypes and grades of adenoma dysplasia, nor between grades of differentiation, extension and proliferation of adenocarcinomas. There was a significant association between Osteopontin expression and the cell proliferation index. No association was observed between the expression of COX-2 and Osteopontin (p = 0.96). Conclusions: Osteopontin overexpression in colon adenocarcinoma and adenomas in comparison with non-tumor colonic mucosa, and its significant relationship with the cell proliferation index, constitutes additional evidence of its possible participation in the colonic carcinogenesis process.

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We previously identified four novel subphenotypes of patients with infection following distinct body temperature trajectories. The four subphenotypes were described as "hyperthermic, slow resolvers" (HSR), "hyperthermic, fast resolvers" (HFR), "normothermic" (NT), and "hypothermic" (HT). These subphenotypes had different demographics, comorbidities, and mortality rates, with the HT patients having a mortality rate three times higher than the HFR. In this study, we applied the trajectory algorithm to patients with septic shock to investigate the association between subphenotype group and bacteremia in this patient population. METHODS: The study prospectively enrolled 120 patients between 2017 and 2019 with septic shock on vasopressors for less than 24 hours. Patients with cardiac arrest, right ventricular failure, end of life discussions, and pregnancy were excluded. Temperature measurements during the first 72 hours from the onset of infection were collected. Patients who died within the 72-hour temperature period were excluded. Patients were classified into one of four trajectory groups using the previously validated groupbased trajectory modeling algorithm. Clinical characteristics and outcomes were compared across these subphenotypes using analysis of variance and chi-squared testing as appropriate.

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