Class A and 25 Child's Class B). Thirty-five prognostic factors were evaluated for their association with overall survival (OS) and disease free survival (DFS) in univar-

We study the asymptotic behavior of estimators of a two-valued, discontinuous diffusion coefficient in a Stochastic Differential Equation, called an Oscillating Brownian Motion. Using the relation of the latter process with the Skew Brownian Motion, we propose two natural consistent estimators, which are variants of the integrated volatility estimator and take the occupation times into account. We show the stable convergence of the renormalized errors' estimations toward some Gaussian mixture, possibly corrected by a term that depends on the local time. These limits stem from the lack of ergodicity as well as the behavior of the local time at zero of the process. We test both estimators on simulated processes, finding a complete agreement with the theoretical predictions.

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We study the maximum likelihood estimator of the drift parameters of a stochastic differential equation, with both drift and diffusion coefficients constant on the positive and negative axis, yet discontinuous at zero. This threshold diffusion is called drifted Oscillating Brownian motion.For this continuously observed diffusion, the maximum likelihood estimator coincide with a quasi-likelihood estimator with constant diffusion term. We show that this estimator is the limit, as observations become dense in time, of the (quasi)-maximum likelihood estimator based on discrete observations.In long time, the asymptotic behaviors of the positive and negative occupation times rule the ones of the estimators.Differently from most known results in the literature, we do not restrict ourselves to the ergodic framework: indeed, depending on the signs of the drift, the process may be ergodic, transient or null recurrent. For each regime, we establish whether or not the estimators are consistent; if they are, we prove the convergence in long time of the properly rescaled difference of the estimators towards a normal or mixed normal distribution. These theoretical results are backed by numerical simulations.

We propose a new class of rough stochastic volatility models obtained by modulating the power-law kernel dening the fractional Brownian motion (fBm) by a logarithmic term, such that the kernel retains square integrability even in the limit case of vanishing Hurst index H. The so-obtained log-modulated fractional Brownian motion (log-fBm) is a continuous Gaussian process even for H = 0. As a consequence, the resulting super-rough stochastic volatility models can be analysed over the whole range 0 ≤ H < 1/2 without the need of further normalization. We obtain skew asymptotics of the form log(1/T ) −p T H−1/2 as T → 0, H ≥ 0, so no attening of the skew occurs as H → 0.