Objectives URB937, a peripheral fatty acid amide hydrolase (FAAH) inhibitor, exerts profound analgesic effects in animal models. We examined, in rats, (1) the pharmacokinetic profile of oral URB937; (2) the compound's ability to elevate levels of the representative FAAH substrate, oleoylethanolamide (OEA); and (3) the compound's tolerability after oral administration. Methods We developed a liquid chromatography/tandem mass spectrometry (LC/MS-MS) method to measure URB937 and used a pre-existing LC/MS-MS assay to quantify OEA. FAAH activity was measured using a radioactive substrate. The tolerability of single or repeated (once daily for 2 weeks) oral administration of supramaximal doses of URB937 (100, 300, 1000 mg/kg) was assessed by monitoring food intake, water intake and body weight, followed by post-mortem evaluation of organ structure. Key findings URB937 was orally available in male rats (F = 36%), but remained undetectable in brain when administered at doses that maximally inhibit FAAH activity and elevate OEA in plasma and liver. Acute and subchronic treatment with high doses of URB937 was well-tolerated and resulted in FAAH inhibition in brain. Conclusions Pain remains a major unmet medical need. The favourable pharmacokinetic and pharmacodynamic properties of URB937, along with its tolerability, encourage further development studies on this compound.

This study presents and describes the anatomical variation of the left vertebral artery arising from the aortic arch in two female cadavers, discovered during dissection in an anatomical laboratory setting. This anomaly was initially discovered during a routine cadaveric dissection of the neck of a 64‐year‐old female cadaver. This finding prompted an evaluation of the remaining twenty‐five cadavers in the lab, leading to the discovery of the same variation in an 83‐year ‐old female. In both cadavers, the left vertebral artery originated from the aortic arch in between the origins of the left common carotid artery and the left subclavian artery. This is a variation, as the vertebral artery is typically known to branch off of the first part of the subclavian artery on both the right and left side. Following this discovery of the anomaly in the laboratory, a literature review was conducted to understand the prevalence of this variation in the general population as well as its clinical implications.

We report the anatomical findings of a kidney discovered in a 92‐year‐old male during a routine dissection of the abdominal viscera performed by medical students at the Oakland University William Beaumont School of Medicine. The lower poles of the kidney are fused together, forming an isthmus anterior to the aorta and inferior vena cava at the L3‐L4 vertebral level. The right and left kidneys ascend past the isthmus, forming a “U” shape, the defining feature of a horseshoe kidney. The left kidney stops prematurely, approximately 3.2 cm below the inferior mesenteric artery at the level of the left inferior renal artery. The right kidney drains into superior, inferior, and middle renal arteries which have three, two, and one branches respectively. Due to the size and position of the hilum, five separate roots extend outside the kidney into the right ureter. The left side is supplied by a superior and inferior renal artery, each dividing into two branches. The left inferior renal artery branches off the ventral face of the descending aorta. The left renal vein notably has three prominent tributaries from the kidney and an additional branch of the left adrenal vein. Six roots extend from the left hilum and drain into the left ureter. In total, the kidney has nine veins, six arteries, and eleven ureteric branches draining into the left and right ureters. These findings will be useful in regard to research and surgery on other horseshoe kidneys.