No abstract

In a one-pot three-component reaction, an aromatic or aliphatic aldehyde, malononitrile and 5-hydroxy-2-hydroxymethyl-4Hpyran-4-one were condensed for the synthesis of 2-amino-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile derivatives in the presence of nano-silica sulfuric acid (SiO 2 -OSO 3 H nanoparticles) in improved yields. The catalyst is recoverable by simple filtration and can be used in the subsequent reactions.

One-Pot Synthesis of 2-Amino-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile Derivatives inWater, a Green Protocol. -The solid phase acidic catalyst is reusable several times without significant loss of activity. -(SADEGHI*, B.; NEZHAD, P. F.; HASHEMIAN, S.; J. Chem. Res. 38 (2014) 1, 54-57, http://dx.doi.org/10.3184/174751914X13866053657371 ; Dep. Chem., Islamic Azad Univ., Yazd, Iran; Eng.) -H. Toeppel 27-156