Recent studies reported that some recovered COVID‐19 patients have tested positive for virus nucleic acid again. A systematic search was performed in Web of Science, PubMed, Scopus, and Google Scholar up to March 6, 2021. The pooled estimation of reinfection, recurrence, and hospital readmission among recovered COVID‐19 patients was 3, 133, and 75 per 1000 patients, respectively. The overall estimation of reinfection among males compared to females was greater. The prevalence of recurrence in females compared to males was more common. Also, hospital readmission between sex groups was the same. There is uncertainty about long‐term immunity after SARS‐Cov‐2 infection. Thus, the possibility of reinfection and recurrence after recovery is not unexpected. In addition, there is a probability of hospital readmission due to adverse events of COVID‐19 after discharge. However, with mass vaccination of people and using the principles of prevention and appropriate management of the disease, frequent occurrence of the disease can be controlled.

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Background: Cancer incidence is a major public health concern and one of the leading causes of premature death worldwide. Therefore, this study was conducted to determine the death rate and years of life lost (YLL) due to cancer in Iran. Methods: In this study, death registration system (DRS) data in Iran was used. The Global Health Estimates (GHE-2016) cause categories and ICD-10 codes (C00-C97 and D00-D48) were assigned for deaths due to cancer. The crude, age-standardized mortality rates (ASMR) via world standard population was measured, and also YLL due to cancer were calculated using standard life expectancy. Results: The DRS recorded 53,492 deaths due to cancer (58.82% males and 41.18% females). The cancer mortality rate was 66.92 per 100,000 population (77.7 and 55.87 per 100,000 population in men and women, respectively) and ASMR was 96.4 per 100,000 population (115.7 and 77 per 100,000 population for males and females, respectively). The total YLL due to premature death was 736,564 in males, 580,254 in females, and 1,316,818 in both sexes. Death due to stomach cancer, tracheal, bronchus, and lung, leukemia, brain, and nervous system cancer, and breast cancer comprised the largest YLL category among different cancer sites. Conclusions: Accounting for more than 1,300,000 YLL attributed to cancer, it is a major public health problem in Iran. Therefore, promoting the prevention and control programs and policies are necessary to improve health indicators and since some cancers are preventable, the burden can be reduced by controlling tobacco use, dietary interventions, and promoting physical activity.

Despite the overall decline in human immunodeficiency virus (HIV) prevalence, it remains unacceptably high in key populations. This study aimed to estimate prevalence of HIV infection and high-risk behaviors among female sex workers (FSWs). This study was a cross-sectional survey of FSWs conducted between December 2019 and August 2020 in eight geographically diverse cities in Iran. After providing informed consent, participants completed a bio-behavioral questionnaire and after completion of the interview, rapid diagnostic tests (RDT) and dried blood spots (DBS) were collected to determine HIV and syphilis status as per national guidelines, if the women consented. All analyzes were based on RDS adjustment. Weighting was done according to Giles’SS estimator. Among the 1515 FSWs, the overall prevalence of HIV and syphilis were 1.6% (95% CI: 0.8–2.3) and zero, respectively. The highest HIV prevalence was observed in Shiraz (5.1%) and Khorramabad city (1.6%). In addition, HIV-positive FSWs had a higher mean age at first sexual contact than HIV-negative FSWs (21.4 ± 5.6 vs. 17.2 ± 4.2 years). Injection drug use and a history of arrest or incarceration were associated with an increased odds of HIV infection (OR = 6.25; 95% CI: 1.90-20.55 and OR = 4.57; 95% CI: 1.64–12.72, respectively). Based on the results, strategies to improve early HIV diagnosis, harm reduction, and use of testing and treatment strategies are needed to reduce and control HIV infections.

Background: Constipation is one of the most common complaints in children. Guidelines on functional constipation recommend digital rectal examination (DRE) when constipation is suspected. However, diagnosis of megarectum by ultrasonography would differentiate children with constipation from those with dysfunctional defecation. Objectives: In this research, we evaluated the utilization of ultrasonography to measure the diameter of rectal ampulla for the diagnosis of functional constipation. Methods: In this study, 94 patients < 14 years old diagnosed with functional constipation were included. Patients were examined by both DRE and ultrasonography before and after a conventional stool softener treatment. Results: The diameter of the rectal ampulla was significantly wider in patients with large stool mass in DRE than in patients with normal digital rectal exams. There was a significant relationship between fecal incontinence and pre-treatment DRA. By increasing the severity of fecal incontinence, the average DRA in patients increased significantly. Additionally, there was a significant statistical difference between the patient’s DRA before and after treatment. Finally, the relationship between constipation and DRA adjusted model showed that the risk of abnormal DRA was 3.1 times larger in patients with three and four symptoms than in patients with two symptoms and this relationship was statistically significant. Conclusions: Ultrasonography can be a suitable replacement for DRE; however, further investigations are required.