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Alzheimer’s disease (AD) is a severe neurodegenerative disorder that affects a growing worldwide elderly population. Identification of brain functional biomarkers is expected to help determine preclinical stages for targeted mechanistic studies and development of therapeutic interventions to deter disease progression. Connectomic analysis, a graph theory-based methodology used in the analysis of brain-derived connectivity matrices was used in conjunction with percolation theory targeted attack model to investigate the network effects of AD-related amyloid deposition. We used matrices derived from resting state functional magnetic resonance imaging collected on mice with extracellular amyloidosis (TgCRND8 mice, n = 17) and control littermates (n = 17). Global, nodal, spatial, and percolation-based analysis was performed comparing AD and control mice. These data indicate a short-term compensatory response to neurodegeneration in the AD brain via a strongly connected core network with highly vulnerable or disconnected hubs. Targeted attacks demonstrated a greater vulnerability of AD brains to all types of attacks and identified progression models to mimic AD brain functional connectivity through betweenness centrality and collective influence metrics. Furthermore, both spatial analysis and percolation theory identified a key disconnect between the anterior brain of the AD mice to the rest of the brain network.

Objective This paper seeks to advance the discussion of foreign language automatisms and clinical consequences of Non-Convulsive Status Epilepticus (NCSE) such as post-ictal psychosis. We present the first case of a monolingual English speaker communicating solely in Spanish, a non-native language during an epileptic episode. Method A 70-year old man with no history of seizures, epilepsy, or psychiatric illness presented to his primary care provider with episodes of confusion and "speaking Spanish." Prolonged video EEG performed after admission demonstrated a disorganized background with a mixture of generalized theta and delta activity with frequent focal and generalized ictal and epileptiform activity occurring predominantly out of the right hemisphere. Results Laboratory evaluation punctures were unrevealing. MRI of the brain with and without contrast were both normal. Keppra and Depakote were continued during the admission. His psychosis and cognitive impairment improved slowly over several days though he did not return back to his neurological baseline. He returned to speaking only English after several days of treatment. He continued to have frontal lobe dysfunction with psychotic features. A diagnosis of rapidly progressive dementia of unclear etiology was given. Conclusion Though foreign language automatisms are a rare consequence of NCSE, the combination of psychotic symptoms and confusion presented in this case creates an interesting connection between psychosis, dementia syndromes, and epilepsy, all involving aberrant activity or deficits in similar brain regions. The generation of foreign language automatisms may indicate a form of psychotic symptomology manifesting as a language anomaly as opposed to visual hallucinations, delusions, or formal thought disorder.

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Objective The objective of this case is to spotlight the potential neurological andneuropsychiatric symptoms associated with COVID-19. Method A 55-year-old African American male with a history of schizophrenia, bipolar disorder, obesity, tobacco use, and hypertension voluntarily presented to the local hospital with auditoryhallucinations and delusions. During an inpatient stay, the patient developed symptomsconsistent with COVID-19 and subsequently tested positive for the virus. Thirty-nine days after the initial positive COVID-19 test result, he remained in a coma with retained brainstem responses. An EEG demonstrated encephalopathy and MRI showed multiple, well-circumscribed white matter lesions consistent with acute demyelination (Figure 1). After three days of high-dose steroids and over a month in a coma, the patient began following simple commands. Unfortunately, on hospital day 66, the patient developed sudden hypotension and worsening respiratory status. Results While psychotic episodes in relation to COVID-19 are not widely reported, psychotic episodes are shown in three COVID-19 cases. Other reports have found significant changes in consciousness in COVID-19 patients with delayed awakening from a comatose state. Pre-existing inflammatory responses in those with psychiatric disease may be accelerated by the immune response due to COVID-19. Conclusion Mental status changes in those with psychiatric illness who have COVID-19 are worth exploring. It is unclear whether a history of COVID-19 may accelerate a neuropsychiatric process or other central nervous system diseases. Future research may want to examine the possible interrelationship between pre-existing neurological vulnerabilities and COVID-19. The possibility of high-dose steroid treatment for COVID-19 neuroinflammatory complications should be considered.