Aim: The study aimed to evaluate and compare the shear bond strength (SBS) at the interface of monolithic zirconia with zirconomer (Zr) core build-up, a new type of glass ionomer cement to monolithic zirconia with composite resin core build-up material. Setting and Design: In vitro a comparative study. Materials and Methods: A total of 32 disk-shaped samples of monolithic zirconia and two distinct core build-up materials: Zr ( n = 16) and composite resin ( n = 16) were used. The two components, monolithic zirconia with Zr core build-up and monolithic zirconia with composite resin core build-up, were bonded using zirconia primer and self-adhesive, dual-cure cement. The samples were subsequently thermocycled, and the SBS was tested at their interfaces. The failure modes were determined using a stereomicroscope. Data were evaluated using the descriptive analysis for mean, standard deviation, confidence interval, and independent t- test for intergroup comparison. Statistical Analysis Used: Descriptive analysis, independent t-test, Chi-square test. Results: The mean SBS (megapascals) of monolithic zirconia to Zr core build-up (0.74) was statistically significant when compared to monolithic zirconia with composite resin core build-up material (7.25) ( P ≤ 0.001). Zirconomer core build-up showed 100% adhesive failure; composite resin core build-up had 43.8% cohesive, 31.2% mixed, and 25.0% adhesive failures. Conclusion: When evaluating the two core build-up materials’ bindings to monolithic zirconia, Zr and composite resin core build-up showed statistically significant differences. Although Zr has been demonstrated to be the optimal core build-up material; however, additional investigation is required to determine how it bonds to monolithic zirconia more effectively.