Purpose: Cancer is an example of the most important growing diseases in human society and scientists are trying to treat it without considerable side effects on patient's health. Solid lipids are colloidal nanoparticles that were used in drug delivery due to their several advantages. Methods: In this work, surface modified targeted solid lipid nanoparticles (SLNs) were fabricated by nano-homogenizer using tripalmitin glyceride and stearic acid as lipid constituents. The size of nanoparticles and morphological evaluations were surveyed using particle size analyzer, scanning electron microscopy; Fourier transforms infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). Results: The particle size of 148.5 and appropriate polydispersity index were achieved for lipid nanoparticles with an entrapment efficiency of 86.1%. The FT-IR analysis confirmed the coupling of lysine to the free functional group of SLNs. DSC proved the conjugation of amino acid to the surface of carriers. The in vitro epirubicin (EPI) release test exhibited the further controlled release phenomenon for the lysine conjugated nanoparticles. The cytotoxicity assay showed lower IC50 of lysine conjugated SLNs of EPI on the investigated cell line. Conclusion: These studies showed that the fabricated targeted carrier has a very remarkable anticancer effect on breast cancer cell lines in comparison with pure drug.

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In this study, the divergent and magnetic separation method is employed to prepare polyamidoamine (PAMAM) dendrons functionalized magnetic graphene oxide (MGG3) using graphene oxide supported MnFe2O4 nanoparticles as the support (MG), and ethylenediamine (EDA) and methylacrylate (MA) as the precursors of PAMAM dendron. Finally, palladium ions as active catalytic sites are immobilized on the support (MGG3‐Pd). The morphology and structure of the MGG3‐Pd nanocomposite thus produced are characterized by elemental analysis, Fourier transform infrared (FT‐IR), powder X‐ray diffraction (XRD) analysis, thermogravimetric analysis (TGA), field emission scanning electron microscopy (FE‐SEM), transmission electron microscopy (TEM), energy dispersive X‐ray spectroscopy (EDS), inductively coupled plasma atomic emission spectroscopy (ICP‐AES), X‐ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and Zeta potential analysis. Subsequently, the catalytic activity of the MGG3‐Pd nanocomposite is studied in the reaction of 4‐nitrophenol (4‐NP) with sodium borohydride as the reducing agent at room temperature. The MGG3‐Pd catalyst is found to exhibit an excellent catalytic activity in the reduction of 4‐NP with a high yield over a short reaction time and at a rate constant (k) of 16.82 × 10−3 s−1. Furthermore, the MGG3‐Pd catalyst thus produced can be recycled at least after 10 runs of 4‐NP reduction without any considerable loss of Pd content. The reduction of other nitroaromatic compounds is also investigated under optimal conditions to illustrate the catalyst's versatility.