Efficient and wise management of freshwater resources in South Africa has become critical because of the alarming freshwater scarceness. The situation requires a thorough examination of how water is utilized across various departments that use water. This paper reports on an examination of the water footprint and economic water productivities of the wheat-bread value chain. The assessment methodology of the Water Footprint Network was employed. The findings reveal that 954.07 m3 and 1026.07 m3 of water are utilized in the production of a ton of wheat flour in Bainsvlei and Clovelly in South Africa. The average water footprint for wheat bread was 954.53 m3 per ton in Bainsvlei and 1026.53 m3 per ton in Clovelly. More than 99% of the water is used in producing the grain at the farm level. The processing stage of the value chain uses less than 1% of the total water footprint. About 80% of all the water utilised along the wheat bread value chain is attributed to blue water. The findings revealed a significant shift from green water consumption to higher blue water use, and this is a major concern for water users and stakeholders along the wheat-bread value chain, given that blue water is becoming scarce in South Africa. The groundwater contributes about 34% and 42% of the average total water footprint of wheat at the farm level in Clovelly and Bainsvlei, respectively, suggesting the need to have an idea of the contribution of groundwater in water footprint evaluation and water management decision of farmers. This insight will aid in minimizing irrigation water use and pressure on groundwater resources. A total of ZAR 4.27 is obtained for every m3 of water utilized along the wheat-bread value chain. Water footprint assessment has moved away from sole indicator assessment, as a deeper awareness of and insight into the productive use of water at different stages has become vital for policy. To make a correct judgment and to assess the efficient and wise use of water, there is a need for catchment- or region-specific water footprint benchmarks, given that water footprint estimates and economic water productivities vary from one geographical area to another.