Introduction: Stroke is defined by (WHO) World Health Organization as 'a clinical syndrome consisting of rapidly developing clinical signs of focal (or global in case of coma) disturbance of cerebral function lasting more than 24 hour or leading to death with no apparent cause other than a vascular origin.' There are few studies conducted in Indian scenario, which shows the role of serum uric acid in cases of acute ischaemic stroke. So the present study aimed at evaluating role of uric acid in assessing severity of acute ischemic stroke. Material and methods: It was an Analytical, Non interventional Prospective study conducted among 100 cases of acute ischaemic stroke admitted in medicine ward and ICU at Krishna hospital, Karad over the period of 18 months, who fulfilled inclusion criteria were included in our study. Results: In the present study, serum uric acid levels and its distribution was carried out. Mean levels of Serum Uric acid was 4.92 ± 1.89 mg/dl. Maximum value being 8.4 mg/dl and minimum value was 1.2 mg/dl. Conclusion: The severity of acute ischaemic stroke was proved to be directly proportional to the mean serum uric acid levels in the present study.

In this hospital based Case Control study, the patient population consisted of 100 patients of COPD admitted as an acute exacerbation, maximum number of patients of acute exacerbation 45% was in the age of 61-70 years, mean age was 66.44 ± 8.19 years. 74 patients were males, 71% of COPD patients were chronic smokers, 45 (45%) patients were in stage II, and 72% of patients of COPD exacerbation had hypomagnesaemia. In the control group, 99% of patients had normomagnesaemia. The incidence of hypomagnesaemia was 78% with acute exacerbation. The correlation of serum magnesium levels in exacerbation patients moreover, serum magnesium level stable COPD patients was significantly important. There was a significant correlation between hypomagnesaemia and GOLD staging in stage II and stage III, with a non-significant correlation between hypomagnesaemia and stage I and stage IV. The study concludes that COPD exacerbation is associated with hypomagnesaemia. Further studies are needed to find out the correlation between the staging of COPD and serum magnesium levels, and the effect of magnesium therapy in COPD exacerbation patients with hypomagnesaemia. Also, further studies are needed to find out possible aetiology of hypomagnesaemia in COPD exacerbation.

Introduction:Cardiac dysfunction in patients with cirrhosis occurs in the setting of a circulatory dysfunction characterized by a marked splanchnic arterial vasodilation. Circulatory changes can lead to the cardiac dilatation of the left chambers and the development of functional changes in the heart. The present study is intended to assess cardiac functions in patients of liver cirrhosis.Material and methods: It was a cross sectional study conducted among 74 diagnosed cases of liver cirrhosis, admitted to department of general medicine, KIMS Hospital during the 6 months study duration. Results:Overall LVDD was diagnosed in 59 cases (79.73%). Out of which, 47.29% cases presented with Stage 1 (impaired relaxation) LVDD, Stage 2 LVDD (pseudo normal) among 31.08% and only one patient had severe restrictive type of (Stage 3) LVDD. Conclusion:Left ventricular diastolic dysfunction is commonly associated with advancement of hepatic dysfunction while systolic function is maintained till advanced hepatic failure.

Introduction: Diabetes mellitus is a complex metabolic disorder associated with an increased risk of microvascular and macrovascular disease. Type 2 diabetes mellitus is a prevalent metabolic disorder that often leads to cardiovascular diseases and diabetic cardiomyopathy, which may lead to chronic pressure overload and myocardial infarction. The present study aimed at studying the extent and complexity of cardiovascular lesions among diabetic patients and compare same with non-diabetic patients. Materials and methods: The present study was a Case-Control (Analytical and Interventional) Study conducted over 18 months (October 2016 to March 2018). Case group consisted of 250 Diabetic patients with cardiac symptoms, with or without ECG changes, who have undergone coronary angiography. And Controls group consisted of 250 Non-Diabetic patients with cardiac symptoms, with or without ECG changes, have undergone coronary angiography. Results: In the present study, among diabetics, there were 52.8% male patients and 47.2% female patients, similarly among non diabetic group, 57.2% were males and 42.8% cases were females. 12.4% people were found normal, 37.6% were suffering from Single vessel disease, 28.8% people with Double vessel disease and 21.2% people with Triple vessel disease. Conclusions: According to the present study, among coronary angiography diagnosis, severe forms of coronary artery lesions were found common among diabetic patients as compared to non diabetic patients.