This study examined the relationships between personal characteristics, social support, spiritual well-being, coping style and adaptation process, and quality of life (QOL) among Thai people living with HIV infection (Thai PLWH) in Suphanburi Province, Thailand. Predictors of QOL were also investigated. Molassiotis's Quality of Life Assessment in Chronic Patients provided the theoretical framework for this descriptive correlational design. The sample consisted of 120 Thai PLWH. Multiple regressions were used to estimate correlates between the independent study variables and QOL in Thai PLWH. The results revealed that age, education level, employment status, monthly income, living in own house, living with family member, social support, spiritual well-being, and coping style and adaptation process were related to QOL. This study provides a backdrop for the implementation of nursing interventions that will be designed to reshape QOL among Thai PLWH.