No abstract

No abstract

Qualitative and quantitative estimation plays a key role in ensuring the safety and efficacy of drugs in different matrices. A detailed literature survey is one of the most essential requirements for all focused research activities. Sofosbuvir is the drug of choice for Hepatitis C virus infection with a high cure rate. It inhibits RNA polymerase enzyme which is responsible for replication of hepatitis C virus RNA. Sofosbuvir was approved by the U.S. Food and Drug Administration (FDA) in 2013. Sincere effort has been made in the present review to collate all the relevant literature published in various pharmaceutical journals for determination of sofosbuvir in different matrices both individually and in combination with other drugs. The review highlights the basic as well as advanced techniques performed for estimating sofosbuvir. Among different methods, HPLC and UV-Visible spectrophotometry are the most widely used techniques applied by the researchers. Detailed validation parameters are also given for the methods, which helps the researchers to select an analytical technique based on the information sought.