This is a review of attempts to integrate psychotherapeutic techniques derived from religious/spiritual and secular psychological perspectives including findings from the cognitive-behavioral, psychodynamic, existential-humanistic, and health psychology areas. While research evidence is not abundant, traditional approaches are being applied to spiritual concerns, and spiritual thought is being extended into clinical domains. Caveats abound, but on the whole, commonalities are plentiful and rapprochement is evidenced where neglect formerly existed. Empirical and theoretical efforts have yielded seminal strategies for coping with therapeutic issues laced with spiritual/religious meaning. Working within the clients' value framework is emphasized while being cognizant of one's own values and biases. The use of prayer, forgiveness, scriptural reference or imagery need not be limited to committed believers although understanding and appreciation of these spiritually-derived approaches are essential. There is progress toward compatibility, complementarity, and cohesion among these diverse components of psychotherapy.