BACKGROUND Conventional therapies for deep cutaneous vascular anomalies have demonstrated poor efficacy and many side effects. New laser systems offer greater potential to treat these difficult lesions, but the lack of specific treatment guidelines has restricted consistent success. OBJECTIVE To establish a rational, user‐friendly algorithm that incorporates basic components of deep vascular lesions to define the correct laser settings required for safe, effective, and reproducible treatment. METHODS Within 18 months, 162 deep vascular lesions of various types and anatomic sites were evaluated for vessel size, depth, color, and pressure. An algorithm incorporating these characteristics was employed to determine laser parameter settings. Using a high‐peak power, long‐pulse 1064‐nm Nd:YAG laser system, the vascular lesions were then treated. RESULTS Within 6 months of follow‐up, 80% of treated areas demonstrated a 50% or greater resolution after a single treatment session, with complete clearance shown in 19%. Only minimal and transient side effects were observed. Of note, 74% of areas on the extremities and 83% within the oral cavity showed a 50% or greater resolution after one treatment. CONCLUSION Previously challenging deep cutaneous vascular anomalies may be safely reduced or cleared with the use of an appropriate laser system and this algorithm‐directed technique. This represents a significant breakthrough in the management of vascular lesions.

SUMMARY A retrospective study of all cases of iris melanoma in Northern Ireland over a 15-year period was undertaken. A total of 18 cases were identified. Of these, nine were histologically proved to be iris melanomas of various types. Within the period of follow-up two patients died from metastatic deposits. In both cases invasion of the anterior face of the ciliary body was present on histological examination. The implications for management are discussed.

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We report the case histories of three patients with untreated malignant melanoma of the choroid or ciliary body. Metastatic disease which resulted in death was diagnosed four years in two patients and 13 years in one patient after the diagnosis of choroidal melanoma was suspected. The diagnosis of malignant melanoma was confirmed by histopathology in two of these patients.