The results of this study indicate that the RS assay impacts medical oncologist adjuvant treatment recommendations, patient treatment choice, and patient anxiety.

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Background Clinically significant depression is present in 25 % of individuals with type 2 diabetes, its risk being doubled in women. Purpose To examine the effectiveness of the Study of Women's Emotions and Evaluation of a Psychoeducational (SWEEP), a group therapy for depression treatment based on cognitive behavioral therapy principles that was developed for women with type 2 diabetes was conducted. Methods Women with significantly elevated depression symptoms (Center for Epidemiologic Studies Depression Scale ≥16) were randomized to SWEEP (n=38) or usual care (UC, n=36). Results Multilevel modeling indicated that SWEEP was more effective than UC in reducing depression (mean difference of –15 vs. –7, p<.01), decreasing trait anxiety (mean difference of –15 vs. –5, p<.01), and improving anger expression (mean difference of –12 vs. –5, p<.05). Although SWEEP and UC had improvements in fasting glucose (mean difference of –24 vs. –1 mg/dl) and HbA1c (mean difference of –0.4 vs. –0.1 %), there were no statistically significant differences between groups. Conclusions SWEEP was more effective than UC for treating depressed women with type 2 diabetes. Addition of group therapy for depression meaningfully expands the armamentarium of evidence-based treatment options for women with diabetes.