trabajo investigación efecto de miconazol sobre el recuento de levaduras en candidiasis asociada a estomatitis protésica.Effect of miconazole on the yeast count in candidiasis associated with denture stomatitis. resumen introducción: Estomatitis Subprotésica, proceso inflamatorio crónico de la mucosa adyacente a prótesis removible. 71,4% de los sujetos con esta condición es portador de Candida y la severidad se relaciona con la presencia de esta levadura. Para su tratamiento se indica antimicóticos tópicos de la familia de polienos o de azoles. El propósito del estudio fue determinar el recuento de levaduras del género Candida en adultos mayores con candidiasis oral, antes y después de ser tratados con miconazol. materiales y métodos: Se consignaron antecedentes sistémicos y locales en 32 adultos mayores con estomatitis subprotésica. Se determinó recuento de levaduras del género Candida en saliva, antes y después del tratamiento tópico con Miconazol 2%. Se aceptaron diferencias estadísticamente significativas con un error alfa igual o menor a 0.05%. resultados: Los recuentos de levaduras del inicio del estudio disminuyeron significativamente a los días 8 y 15 después del tratamiento (mediana 6.800, 163, 60, respectivamente). 56,2% de los individuos presentó persistencia de levaduras después del tratamiento; 21,8% de ellos con recuentos superiores a 400 UFC/ml de saliva. conclusiones: En el 56,2% de los individuos del estudio se observó persistencia de levaduras del género Candida luego de 2 semanas de tratamiento con miconazol al 2%. Palabras claveEstomatitis subprotésica, Levaduras, Candida, Miconazol.rev. clin. Periodoncia implantol. rehabil. oral vol. 11(2); 102-105, 2018. abstract introduction: Denture stomatitis is a chronic inflammatory process of the mucosa adjacent to removable prosthesis. 71.4% of the subjects with this condition are carriersof Candida and the severity is related to the presence of this yeast. Topical antimycotics belonging to the polyene or azole family are indicated for its treatment. Efficacy of miconazole is reported to be from 80% to 100%, although resistance is described in isolates of Candida. The purposeof the study was to determine the count of Candida in older adults with oral candidiasis,before and after being treated with miconazole. methodology: Systemic and localantecedents were recorded in 32 elderly adults with denture stomatitis. Differences in number of the colony forming units of Candida yeast were determined before and after topical treatment with Miconazole 2%. Statistical significances were set at a value of p< 0.05. results: Yeast counts at the start of the study significantly decreased 8 and 15 days after treatment (median 6,800, 163, 60, respectively). 56.2% of the subjectspresented persistence of yeasts after treatment; 21.8% of them with counts higherthan 400 CFU / ml saliva. conclusion: In 56.2% of the study subjects, persistence of Candida yeasts was observed after 2 weeks of treatment with 2% miconazole.
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