Introduction: Epidermolysis bullosa (EB) is a rare disease with skin fragility that develops blisters with a minimum trauma. Feet blisters are a challenge to develop walking milestone. Shoes are the primary interface between the body and the ground, protecting feet and affecting how ground reaction forces are applied to the foot and transferred to the entire body. The effect of shoes on children’s gait is poorly understood, especially in children with EB. The selection of appropriate footwear may help reduce blisters and improve foot function in EB. Case Report: This case report investigated the use of Biomimetic Shoe over EB’s child gait. We tested a commercially available shoe for toddlers that used sand as a model to develop its midsole. As a nature-inspired design, this shoe claims to respect the morphology of the toddler’s feet and provide better conditions for foot development. Conclusion: Offering walking experiences similar to barefoot conditions improved the child walking pattern, empowering the child to stay mobile and allowing the foot to function as it would naturally.