The association of positive HLA-DQ2/DQ8 and serologic testing has a high predictive value for CD. We suggest that symptomatic children with high titers of immunoglobulin (Ig)A tTG could be diagnosed as patients with CD without performing jejunal biopsy. In other children, HLA-DQ2/DQ8 could be useful to exclude the diagnosis of CD if negative. In cases of low IgA tTG titers or in patients with IgA deficiency, intestinal biopsy remains mandatory.

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of SLE, and had active disease involving skin or joints. RNA isolated from whole blood at baseline and weeks 2, 4, 12, and 24 was analyzed using Affymetrix HTA2.0 array. Results Gene expression profiling demonstrated a statistically significant elevation of STAT1 and STAT2 gene expression at baseline in SLE patients. There was a significant association between the overexpression of STAT1 and STAT2 at baseline. Baricitinib 4-mg treatment resulted in modest reduction in STAT1, STAT2, and STAT4 expression, and a statistically significant reduction in multiple genes downstream of STAT1, STAT2, and STAT4. The reduction in expression of STAT-associated genes with baricitinib treatment correlated with clinical improvement in SLE patients using SLEDAI-2K measurements (table 1). Conclusions Baricitinib may partially mediate its effect in SLE through changes in STAT-related gene expression, with changes associated with clinical improvement in SLE. Acknowledgements Funded by Eli Lilly and Company.

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