Summary Conserving viable large carnivore populations requires managing their interactions with humans in increasingly anthropogenic landscapes. Faced with declining budgets and escalating wildlife conflicts, agencies in North America continue to grapple with uncertainty surrounding the efficacy of socially divisive management actions such as harvest to reduce conflict. We used multistate capture–reencounter methods to estimate cause‐specific mortality for a large sample (>3500) of American black bears Ursus americanus in north‐western New Jersey, USA over a 33‐year period. Specifically, we focused on factors that might influence the probability of bears being harvested, lethally managed, or dying from other causes. We further analysed temporal correlations between >26 000 human–black bear incidents reported between 2001 and 2013 and estimates of total mortality rates, and specifically, rates of harvest from newly implemented public hunts and lethal management. Adult females were twice as likely (0·163 ± 0·014) as adult males (0·087 ± 0·012) to be harvested during the study period. Cubs (0·444 ± 0·025) and yearlings (0·372 ± 0·022) had a higher probability of dying from other causes, primarily vehicle strikes, than adults (0·199 ± 0·008). Reports of nuisance behaviours in year t + 1 declined with increasing mortality resulting from harvest plus lethal management in year t (P = 0·028, R2 = 0·338). Adult bears previously designated as a nuisance and/or threat were more likely to be harvested (0·176 ± 0·025) than those never identified as a problem (0·109 ± 0·010). Across age classes, individuals assigned problem status, were significantly more likely to be lethally controlled. Synthesis and applications. Given continuing failures in conserving exploited carnivores, their recreational harvest and lethal management remain polarizing. Within this social‐ecological system, the well‐regulated harvest of carefully monitored black bear populations represents a pragmatic approach to achieve population objectives. Furthermore, the integration of harvest and incident‐response management (both lethal and non‐lethal practices) with educational programmes aimed at reducing anthropogenic attractants can result in subsequent reductions in problem behaviours reported.

Chronic neutrophilic leukemia (CNL) is a rare leukemia with approximately 150 total cases reported. Cutaneous neutrophilic infiltrates, including Sweet syndrome (SS) and leukemia cutis (LC), have been reported in six patients with CNL. In the setting of CNL, these two conditions are difficult to differentiate due to clinical and histopathological similarities, but it is important to do so because LC is associated with a worse prognosis. In general, SS is distinguished by its tenderness, fever, and improvement with steroids (vs chemotherapy for LC). Biopsy of LC reveals immature leukocytes, whereas SS shows almost exclusively mature leukocytes, but morphology alone may not be sufficient in some cases. Here, we report a case of a 72‐year‐old male with CNL and a cutaneous eruption with clinical and pathological features which made the distinction between the two diseases difficult.

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We present a novel case of an urticaria multiforme‐type drug reaction to the new cystic fibrosis medication Trikafta (elexacaftor + tezacaftor + ivacaftor). Equipped with this information, clinicians may be more prepared to counsel and treat patients if they experience similar symptoms after beginning Trikafta.