Measurements of the spin-transfer parameter Kr, r, for H(p, n)2p at 0' to calibrate the neutronbeam polarization clarify a normalization discrepancy affecting np data at LAMPF. The new data are in good agreement with theoretical predictions.

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High-throughput chemistry (HTC) is now an integral part of the lead discovery process in many pharmaceutical and related chemical companies. As this process becomes refined or improved, with the integration of systems with enhanced capabilities, and the requirement for quality compounds of high purity increases, purification is often considered a bottleneck. Although a wide range of purification techniques is available, high-performance liquid chromatography (HPLC) is usually the preferred method of purification to produce high-purity compounds. Parallel preparative HPLC with robust UV-guided fraction collection has been shown to reduce the bottleneck and complement the parallel synthesis systems. However, despite the success of this technique, post-purification analysis of fractions to identify the target compound adds an additional level of complexity. This paper describes the interfacing of the Biotage Parallex with the MUX interface on a single quadrupole mass spectrometer, thus combining robust UV-guided fractionation with on-line MS characterization.

We have measured the spin-transfer parameters E~I., E~l., Al. p, and Egg at 635 MeV from 50' to 178' c.m. and at 485 MeV from 74' to 176' c.m. These new data have a significant impact on the phase-shift analyses. There are now sufticient data near these energies to overdetermine the elastic nucleon-nucleon amplitudes.PACS number(s): 21.30. +y, 13.75.Cs, 24.70.+s