In this study, we investigated the toxic effects of water-soluble elements from a contaminated soil via gavage in a single dose, simulating a geophagy event. The contaminated soil was collected in a field located in an industrial complex, and the control soil was collected in a reference area. Metabolic and behavioral parameters in Wistar male rats were measured after 24 and 96 h of gavage. After 96 h, the major organs were weighed, blood was collected to check hematological parameters, the bone marrow was taken for the micronucleus test, and the liver was used for evaluating the total antioxidant capacity, lipoperoxidation and protein carbonylation. Animals exposed to contaminated soil presented a few significant alterations by comparison with control animals: TBARS and protein carbonyl levels increased, the relative weight of the kidneys increased, metabolic parameters (body weight gain, food intake, water consumption, urine and feces production) depressed and there was behavioral alteration. These findings suggest that soils impacted by atmospheric contaminants can affect the organism physiological status jeopardizing the health of populations living in industrial areas. Finally, this study reassures that ingestion of potentially contaminated soils, even for short periods of time, can cause health risks.
Calomys laucha é um pequeno roedor encontrado na América do Sul, em pastagens, áreas agrícolas, margem de estradas e campos de cultivo de cereais. No Brasil, a área de ocorrência do animal está concentrada em dunas costeiras do litoral gaúcho, onde se alimenta e constrói ninhos para reprodução, estando suscetível aos efeitos de atividades antrópicas na região costeira e marinha. O presente estudo teve por objetivo utilizar biomarcadores de dano oxidativo para investigar os efeitos do derrame simulado de petróleo em C. laucha. Os animais (n= 6 por tratamento) foram expostos a cinco diferentes concentrações de petróleo em substrato artificial: 0, 1, 2, 4 e 8 % (v/v). Aproximadamente 1 kg de substrato foi colocado no fundo das gaiolas e os animais machos foram expostos durante 14 dias, com acesso livre a água e ração comercial para roedores. Após esse período, foram recolhidos testículos, fígado e células sanguíneas (linfócitos) para investigação de dano oxidativo em lipídios e proteínas e da capacidade antioxidante contra radical peroxil (ACAP). Os animais expostos ao petróleo demonstraram aumento da peroxidação lipídica nos três homogeneizados analisados, mas as respostas de carbonilação de proteínas e a ACAP foram tecido-dependentes. Estes padrões de resposta distintos sugerem diferenças na distribuição do contaminante no organismo e/ou na capacidade do tecido-alvo em responder a presença dos agentes tóxicos e podem ser úteis para a compreensão dos mecanismos de toxicidade do petróleo em mamíferos silvestres. Por fim, o C. laucha demonstra ser um bom modelo biológico para prever impactos na interface zona costeira/ambiente marinho.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.