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A stable enzyme-phosphoenolpyruvate complex can be formed in partially purified preparations of the phosphoenolpyruvate-uridine-5'-diphospho-iV-acetyl-2-amino-2deoxyglucose 3-O-enolpyruvyl transferase from Micrococcus leisodeikticus, by reaction of phosphoenolpyruvate with the enzyme, and the formation of this complex requires the initial presence of UDP-GlcNAc. A complex with similar properties may be formed by the reverse reaction, upon exposing the enzyme to the reaction products inorganic phos-12, no. 7, 1973

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At least six distinct P-lactam antibiotics of the epithienamycin family are produced by a strain of Streptomyces fiavogriseus MB 4638. Each of the six can be isolated in substantially pure form by column chromatography using Dowex 1, Amberlite XAD-2 and Biogel packings. The structures were established by comparison of the ultraviolet, proton magnetic resonance and mass spectral characteristics with those of thienamycin and its derivatives. All six compounds contain the carbapenem ring system which is also found in thienamycin.They differ from each other and from thienamycin by chemical modifications and/or stereoisomerism. Enzymatically deacetylated epithienamycin A has the properties of an isomer of thienamycin.

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