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Introduction Both prostate cancer and Peyronie’s disease (PD) are prevalent in men after their fifth decade of life. The evidence to support or refute a link between radical prostatectomy (RP) and PD is limited. Aims To define the incidence of PD in men who had RP and determine possible predictors of PD development after RP. Methods A review of a prospectively built sexual medicine database, years 2002–2008, looking at subjects who had RP as a monotherapy for localized prostate cancer. We identified and characterized subjects who developed PD within 3 years after RP and compared them with subjects who did not. Main Outcome Measures The incidence of PD among men who attended a sexual medicine clinic after they had RP, predictors of PD development after RP. Results The study population included 1,011 subjects, and PD incidence in this population was 15.9%. Mean time to develop PD after RP was 13.9 ± 0.7 months. Mean curvature magnitude was 31+17 degrees. On univariate analysis, younger age (mean age of 59+7 in men with PD vs. 60+7 years in men without PD, P = 0.006) and white race (vs non-white, 18% vs. 7%, P <0.001) were predictive of PD development after RP, but post-op erectile function was not a predictor of PD development. On multivariate analysis, younger age (odds ratio (OR)=1.3, for 5-year decrease in age) and white race (OR=4.1, vs. non-white) remained independent significant predictors. Conclusions Men presenting with sexual dysfunction after RP have higher PD incidence then the general population. Therefore, they should be routinely evaluated for PD. Younger men and men of white race are at increased risk for PD. Prospective controlled studies are needed to elucidate the incidence of PD following RP and to conclude if RP has a causative role in the pathogenesis of PD.