Hypercholesterolemia is associated with the atherosclerotic process and cardiovascular disease from childhood, thus introducing the need of an early prevention. The dietary approach is the treatment cornerstone but sometimes is unsuccessful to reach the lipoprotein optimal target. Furthermore, drugs like statins have limited use in childhood as their administration is limited to high risk children. The effects of nutraceuticals are known in adults and considered useful in children to overcome this therapy gap. In the present paper a review of pediatric experiences from fiber, phytosterols and RYR handing out is considered.