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Background and Objectives. This paper presents a study based on Hobfoll’s conservation of resources theory on resources and coping as predictors of the quality of life of those at risk of social exclusion. They are deprived of access to the public pool of psychosocial resources, the acquisition and accumulation of which are closely linked to the perceived quality of life.Design. A cross-sectional self-reported questionnaire study.Method. The sample of 1,074 individuals from various groups at risk of exclusion was surveyed using the Conservation of Resources–Evaluation questionnaire, the Strategic Approach to Coping Scale, and the WHO Quality of Life Questionnaire. Structural equation modeling was used to test mediational hypotheses in the analysis. Results. The significant variables that determined the relationship between resource gains and losses and the quality of life included active-passive and prosocial-antisocial coping strategies. The results were generally robust, but the level of education moderated the relationship between active antisocial coping and quality of life.Conclusion. The obtained dependencies are consistent with Hobfoll’s approach, confirming its usefulness. Prosocial coping boosts the positive prominence of the relationship between resource gains and the quality of life and reduces the effect of resource losses, causing the quality of life to decline.

(1) Background This paper presents a study based on Stevan Hobfoll’s conservation of resources theory and deals specifically with resources and coping as predictors of the quality of life of persons threatened by social exclusion. They have no access to public psychosocial resources, the acquisition and accumulation of which are closely linked to the perceived quality of life. (2) Method A cross-sectional self-reported questionnaire study. A sample of 1,074 individuals from various groups at risk of exclusion was surveyed using the Conservation of Resources-Evaluation Questionnaire, the Strategic Approach to Coping Scale, and the WHO Quality of Life Questionnaire. The research was done among people supported by Polish non-governmental organizations operating nationwide. Structural equation modeling was used to test mediational hypotheses in the analysis. (3) Results The significant variables that determined the relationship between resource gains and losses and the quality of life included active–passive and prosocial–antisocial coping strategies. The results were generally robust, but the level of education moderated the relationship between active antisocial coping and quality of life. (4) Conclusions The obtained dependencies are consistent with Hobfoll’s approach, confirming its usefulness. Prosocial coping mediates the effect of resource gain on the increase in quality of life and the effect of resource loss on the decline in quality of life, strengthening the former and weakening the latter.