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Membrane Lipid Replacement is the use of functional oral supplements containing cell membrane glycerolphospholipids and antioxidants to safely replace damaged membrane lipids that accumulate during aging and in various chronic and acute diseases. Most if not all clinical conditions and aging are characterized by membrane phospholipid oxidative damage, resulting in loss of membrane and cellular function. Clinical trials have shown the benefits of Membrane Lipid Replacement supplements in replenishing damaged membrane lipids and restoring mitochondrial function, resulting in reductions in fatigue in aged subjects and patients with a variety of clinical diagnoses. Recent observations have indicated that Membrane Lipid Replacement can be a useful natural supplement strategy in a variety of conditions: chronic fatigue, such as found in many diseases and disorders; fatiguing illnesses (fibromyalgia and chronic fatigue syndrome); chronic infections (Lyme disease and mycoplasmal

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Membrane Lipid Replacement (MLR) is the use of functional dietary supplements containing cell membrane glycerolphospholipids and antioxidants to safely replace and remove damaged essential membrane phospholipids that accumulate during aging and in various chronic and acute illnesses. Most, if not all, clinical conditions and aging are characterized by cellular membrane phospholipid free radical oxidative damage, resulting in loss of membrane and cellular functions. In particular, loss of mitochondrial function, the key organelle responsible for over 90% of cellular energy production, can result in excess fatigue and other symptoms, and this is a common problem in almost all, if not all, age-related chronic diseases. Clinical trials have shown the benefits of MLR supplements in replenishing damaged membrane phospholipids and restoring mitochondrial function, resulting in reductions in fatigue and other symptoms in aged subjects and patients with a variety of clinical diagnoses. Here we have specifically reviewed the beneficial results of MLR on subjects older than 60 years. MLR provides general membrane and nutritional support during aging and illnesses to improve membrane function and overall health without risk of adverse effects. The case reports here and elsewhere and published clinical trials demonstrate that this is a safe and effective alternative or addition to pharmaceutical approaches for alleviating fatigue, pain, gastrointestinal and other symptoms associated with normal aging and age-related chronic illnesses.Keywords: Aging, Fatigue, Pain, Gastrointestinal symptoms, Phospholipids, Clinical trials, Case reports, Cellular membranes

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