PurposeTo evaluate the relationship between lens position parameters and intraocular pressure (IOP) reduction after cataract surgery in patients with primary open-angle glaucoma (POAG) and in nonglaucomatous patients.MethodsThe main outcomes of this prospective study were percent and absolute IOP change, which were calculated using the preoperative IOP and the IOP 4 months after cataract surgery in POAG and nonglaucomatous eyes. Lens position (LP), defined as anterior chamber depth (ACD) + one-half lens thickness (LT), was assessed preoperatively using parameters from optical biometry. Preoperative IOP, axial length (AL), ACD, LT, relative lens position (RLP), and the ratio of preoperative IOP to ACD (PD ratio) were also evaluated as potential predictors of IOP change.ResultsFour months postoperatively, the average IOP reduction was 2.80 ± 3.83 mm Hg (15.79%) from the preoperative mean of 14.73 ± 2.89 mm Hg for nonglaucomatous eyes. The average IOP reduction was 2.66 ± 2.07 mm Hg (16.98%) from the preoperative mean of 14.86 ± 2.97 mm Hg for POAG eyes. Preoperative IOP, sex, AL, ACD, PD ratio, and LP predicted IOP change in nonglaucomatous eyes. Preoperative IOP and PD ratio predicted IOP change in POAG eyes.ConclusionsIntraocular pressure reduction after phacoemulsification cataract surgery in nonglaucomatous eyes is significantly greater in more anteriorly positioned lenses. Though it did not reach statistical significance in patients with glaucoma, the association of LP with IOP reduction is in the same direction as in nonglaucomatous patients where smaller LP appears to predict greater IOP reduction. Lens position is a simple, easily calculable, accurate, and widely available parameter, which clinicians can potentially utilize in managing glaucoma.

PurposeTo characterize the optic nerve head (ONH) structure in patients with non-arteritic anterior ischemic optic neuropathy (NAION) compared to healthy control subjects using spectral domain optical coherence tomography (SD-OCT) via the enhanced depth imaging method.MethodsIn this prospective, cross-sectional, comparative study, we assessed 66 eyes of 33 patients with unilateral NAION and 31 eyes of 31 healthy normal subjects in an academic institution. The peripapillary nerve fiber layer thickness, disc area, and quantitative parameters of the ONH structures, including the Bruch's membrane opening (BMO) area, anterior laminar depth, and prelaminar thickness and depth were compared between the three groups.ResultsLinear mixed model analysis after adjusting for age, sex, and axial length showed that the BMO area was similar in eyes with NAION (1.89±0.33 mm), their fellow eyes (1.85±0.35 mm), and control eyes (1.88±0.37 mm; all P>0.99). Anterior laminar depth was also similar in the three groups. The mean prelaminar tissue thickness of the NAION eyes was 445±176 μm, which was thinner than the prelaminar tissue of their unaffected fellow eyes (mean, 539±227 μm, P=0.004), but both were thicker than the prelaminar tissue of the normal subjects (mean 243±145 μm, P=0.001 and P<0.001, respectively).ConclusionsThe thick prelaminar thickness is associated with unilateral NAION in the affected and unaffected eyes.

BACKGROUND: Musculoskeletal disorders are very prevalent among dentists. Of these disorders, carpal tunnel syndrome (CTS) is notable. OBJECTIVE: The aim of this study was to investigate the relationship between the occupational and non-occupational risk factors and CTS among dentists. METHODS: It is a cross-sectional study. We evaluated 106 dentists from dental schools in Tehran. We collected data by a general questionnaire, a hand diagram, and physical examination. A nerve conduction velocity (NCV) test was used to confirm the diagnosis of CTS. The analysis was performed using an independent T-test and logistic regressions on SPSS software. RESULTS: The prevalence of CTS among dentists was 17.9%. Significant risk factors of CTS included: vibration exposure greater than two hours per day (OR: 2.5), a wrist diameter ratio of greater than 0.7 (OR: 10.14), and female sex (OR: 13.38). CONCLUSIONS: Exposure to the hand-arm vibration should be considered as an occupational risk factor for CTS in dentists. Female dentists should take more preventive measures.

This study suggested that rs1927914 and rs1927911 were associated with type 2 diabetes mellitus and that rs1927914 was associated with susceptibility to DR in a Han Chinese population.