Genetic influences have an important role in the ageing process. The genetic factors that influence success in bodily ageing may also contribute to the successful ageing of cognitive abilities. A comparative genomics approach found longevity genes conserved between yeast Saccharomyces cerevisiae and nematode Caenorhabditis elegans. We hypothesised that these longevity genes influence variance in cognitive ability and age-related cognitive decline in humans. Here, we investigated six of these genes that have human orthologs and show expression in the brain. We tested AFG3L2 (MIM: 604581, AFG3 ATPase family gene 3-like 2 (yeast)), FRAP1 (MIM: 601231, a FK506 binding protein 12-rapamycin associated protein), MAT1A, MAT2A (MIM: 610550 and 601468, methionine adenosyltransferases I alpha and II alpha, respectively), SYNJ1 and SYNJ2 (MIM: 604297 and 609410, synaptojanin-1 and synaptojanin-2, respectively) in approximately 1000 healthy older Scots: the Lothian Birth Cohort 1936 (LBC1936). They were tested on general cognitive ability at age 11 years. At a mean age of 70 years, they re-sat the same general cognitive ability test and underwent an additional battery of diverse cognitive tests. In all, 70 tag and functional SNPs in the six longevity genes were genotyped and tested for association with cognition and cognitive ageing in LBC1936. Suggestive associations were detected between SNPs in SYNJ2, MAT1A, AFG3L2 and SYNJ1 and a general memory factor and general cognitive ability at age 11 and 70 years. Replication studies for cognitive ability associations were performed in 2506 samples from the Cognitive Ageing Genetics in England and Scotland consortium. A meta-analysis replicated the SYNJ2 association with cognitive abilities (lowest P¼0.00077). SYNJ2 is a novel gene in which variation is potentially associated with cognitive abilities.

etwork management systems have become an increasingly important part of today's computer networks. As the complexity of networks increases, so have the requirements of the systems managing these networks. These requirements include providing standard interfaces for information sharing among management systems, having extensibility for handling change quickly, and providing a means to minage large networks.One possible approach to handle these requirements is to design an open, standards-based, extensible, and distributed network management system using CORBA. The CORBA interface to the system facilitates easy communication with other systems. Its extensible nature allows the system to grow in future. Finally, CORBA's distributed capabilities make it possible to manage large numbers of nerwork devices in a scalable manner.ProSphere is a CORBA-based [1,8] distributed network management system for General DataComm's (GDC) Asynchronous Transfer Mode (ATM) product line. This product line includes network edge and backbone ATM switches, which are deployed in many telecommunications carriers and private networks worldwide.The ProSphere architecture consists of a set of CORBA servers, which provide Network Management Services; and Java client applications that present information from the servers in graphical interfaces. The architecture is extensible, allowing new kinds of network devices to be supported with little or no change to existing software. The architecture is open, allowing end-user (customer) integration through CORBA Interface Definition Language (IDL) interfaces. The architecture is portable-Java clients can run from any type oi host machine or Web browser. Finally, the ProSphere architecture is distributed in that the system comfxments (clients, servers, and objects) can reside in separate processes and hosts. We describe the ProSphere architecture here and show how it benefits from the use of CORBA. | i Background

Diffuse lymphadenopathy because of VL is a very atypical presentation for infection acquired in the Middle East. Clinicians must be mindful of the extreme immune dysfunction that occurs as a result of this potentially fatal infection and the associated complications to include EBV-related lymphoproliferative disorders and lymphoma.

No abstract

No abstract