Eocene early-diverging representatives of South American extinct notungulates are traditionally considered to have been "generalists" and "non-specialized" in terms of the appendicular skeleton and locomotor behavior, as is the case with the notostylopid Notostylops, a middle Eocene iconic taxon from Patagonia (Argentina). However, they are mainly known from dental remains, and associated cranial and postcranial elements are scarce. The discovery of a nearly complete specimen attributed to N. murinus allows us to: (1) increase the knowledge of the anatomy of its appendicular skeleton; (2) identify isolated bones from several collections and suggest different taxonomic interpretations for published specimens; (3) perform a biomechanical and functional study using functional morphological analysis to infer its paleoecological attributes (e.g. posture, locomotor habit, estimated speed, and body mass); and (4) establish morphofunctional comparisons, based on possible functional ranges, with other extinct earlydiverging notoungulates from the middle Eocene, such as the Notopithecid Notopithecus. Our evidence suggests that Notostylops was a medium-sized mammal (8.5−20 kg), which could achieve a dynamic digitigrade posture that allowed a scansorial secondary locomotor habit and a speed of up to 50 km/h. However, Notopithecus was a small-sized mammal (0.6−1.4 kg) with a plantigrade posture both in a static and dynamic context, terrestrial habits, and a speed of up to 35 km/h. Therefore, we conclude that these Eocene notoungulates show different locomotor capabilities, which can be associated with early niche diversifications, clearly contrasting with the "all-generalists" paradigmatic view.
Introducción. El cáncer de mama (CM) es la enfermedad crónica no transmisible más frecuente y letal en mujeres. La información disponible sobre el impacto de sus diversos tratamientos en el sistema respiratorio es controversial.Objetivo. Determinar el efecto del tratamiento con quimioterapia y radioterapia concomitante en los volúmenes pulmonares de un grupo de mujeres con CM en Talca, Chile.Materiales y métodos. Estudio de casos y controles. La muestra (n=22) se dividió en dos grupos: control (n=11) y con CM (n=11). Para medir la capacidad vital forzada, los volúmenes pulmonares y la resistencia de las vías aéreas, se usó la prueba de pletismografía corporal. Para determinar la normalidad de los datos, se usó la prueba Shapiro-Wilks y, según sus resultados, se utilizó la prueba de t-Student o la de U de Mann-Whitney; se consideró un nivel de significancia de p<0.05.Resultados. Los flujos ventilatorios no presentaron diferencias significativas entre los dos grupos, mientras que los volúmenes pulmonares en el grupo con CM experimentaron una disminución significativa en las variables capacidad inspiratoria (CI) y volumen residual (VR) (p<0.05).Conclusión. Las mujeres con CM y que fueron tratadas con quimioterapia y radioterapia concomitante experimentaron una disminución en su CI y su VR en comparación con el grupo control, lo que podría impactar su calidad de vida.
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