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Marine gateways play a critical role in the exchange of water, heat, salt and nutrients between oceans and seas. As a result, changes in gateway geometry can significantly alter both the pattern of global ocean circulation and associated heat transport and climate, as well as having a profound impact on local environmental conditions. Mediterranean-Atlantic marine corridors that pre-date the modern Gibraltar Strait, closed during the Late Miocene and are now exposed on land in northern Morocco and southern Spain. The restriction and closure of these Miocene connections resulted in extreme salinity fluctuations in the Mediterranean, leading to the precipitation of thick evaporites. This event is known as the Messinian Salinity Crisis (MSC). The evolution and closure of the Mediterranean-Atlantic gateways are a critical control on the MSC, but at present the location, geometry and age of these gateways is still highly controversial, as is the impact of changing Mediterranean outflow on Northern Hemisphere circulation. Here, we present a comprehensive overview of the evolution of the Late Miocene gateways and the nature of Mediterranean-Atlantic exchange as deduced from published studies focussed both on the sediments preserved within the fossil corridors and inferences that can be derived from data in the adjacent basins. We also consider the possible impact of evolving exchange on both the Mediterranean and global climate and highlight the main enduring challenges for reconstructing past Mediterranean-Atlantic exchange.

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In the first wave of the COVID-19 pandemic (April 2020), SARS-CoV-2 was detected in farmed minks and genomic sequencing was performed on mink farms and farm personnel. Here, we describe the outbreak and use sequence data with Bayesian phylodynamic methods to explore SARS-CoV-2 transmission in minks and humans on farms. High number of farm infections (68/126) in minks and farm workers (>50% of farms) were detected, with limited community spread. Three of five initial introductions of SARS-CoV-2 led to subsequent spread between mink farms until November 2020. Viruses belonging to the largest cluster acquired an amino acid substitution in the receptor binding domain of the Spike protein (position 486), evolved faster and spread longer and more widely. Movement of people and distance between farms were statistically significant predictors of virus dispersal between farms. Our study provides novel insights into SARS-CoV-2 transmission between mink farms and highlights the importance of combining genetic information with epidemiological information when investigating outbreaks at the animal-human interface.