p53 nuclear overexpression has independent prognostic value for survival in patients with invasive bladder cancer treated with neoadjuvant chemotherapy.

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✓ Ventriculography in seven infants who had developed hydrocephalus after surviving neonatal meningitis and ventriculitis disclosed intraventricular septations or veils. These post-inflammatory septations compartmentalized the ventricular system, interfering with attempted shunting procedures. Pathogenesis and treatment are discussed.

The stage of bladder cancer at presentation and at postchemotherapy pathologic staging are independent prognostic factors for long-term survival in patients treated with neoadjuvant chemotherapy. Downstaging after neoadjuvant chemotherapy was associated with improved survival in patients with muscle-invasive bladder cancers, but only for those with extravesical disease (T > or = 3B) pretreatment. Randomized comparisons will be required to assess the impact of chemotherapy on overall survival.

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