RESUMO:Introdução: O transplante de fígado (TF) continua sendo o melhor tratamento para pacientes, bem selecionados, portadores de carcinoma hepatocelular. Os critérios de Milão (CM) ( tumor único até 5 cm e 3 tumores não maiores que 3 cms) são os critérios mais usados para estes pacientes. Nosso objetivo é avaliar a situação atual dos CM principalmente a sobrevida do paciente e a taxa livre de recorrência tumoral após 1 a 5 anos do TF, nos últimos 10 anos. Material e Métodos: Revisamos 59 trabalhos entre 200-2009; da Asia (42,3%), Europa (33,9%) e da América do Norte (20,4%). 5.525 pacientes submeteram-se ao TF com os CM. A sobrevida total dos pacientes e a taxa livre de recorrência tumoral foram analisados. Resultados: A taxa de sobrevida total dos pacientes foi em 1 ano de (87,26%), 2 anos (81,95%), 3 anos (77,47%), 4 anos (75,24%) e 5 anos (72,41%). A taxa livre de recorrência tumoral foi de 80,29% e 71,36% em 1 e 5 anos, respectivamente. Conclusão: A melhor taxa de sobrevida dos pacientes foi na América do Norte (88%) e na Asia (76,6%), respectivamente. Por outro lado, a Europa teve a melhor taxa livre de recorrência de doença em 5 anos (91,8%). DEScRitORES:Transplante de fígado/normas; Carcinoma hepatocelular/terapia; Seguimentos. remains an excellent treatment approach for HCC in well-selected candidates. Milan Criteria (MC) (a single tumor up to 5cm or up to 3 tumors none larger than 3.0 cm) is the most widely used criteria for selection of those patients. Our aim is to study the current situation of the MC focusing on patient survival and tumor recurrence free rate from 1 to 5-yrs after OLT over the past 10 years. Material and Methods: We have reviewed 59 papers published between 2000-2009; from Asia (42.3%), Europe (33.9%) and North America (20.4%). 5.525 patients have undergone OLT within MC. The overall patient survival rate and tumor recurrence free rate from 1 to 5-yrs were analyzed. Results: Overall patient survival rates were 1 year (87.26%), 2 years (81.95%), 3 years (77.47%), 4 years (75.24%) and 5 years (72.41%). We have found tumor recurrence free rate of 80.29% and 71.36% at 1 and 5-yrs, respectively. Conclusion: MC has come to simplify the indication for LT in patients with HCC. The best patient survival rate at 1 and 5 years were in North America (88%) and Asia (76,6%), respectively. On the other hand, Europe had the best tumor recurrence free rate at 5 years (91.8%). Rev Med (São Paulo

Type V collagen (Col V) is a "minor" component of normal lung extracellular matrix, which is subjected to decreased and abnormal synthesis in human lung infiltrating adenocarcinoma. We previously reported that a direct link between low amounts of Col V and decreased cell apoptosis may favor cancer cell growth in the mouse lung after chemical carcinogenesis. Moreover, this collagen species was able to trigger DNA fragmentation and impair survival of neoplastic cells. In this study, we have extended our investigation with the aim to obtain further evidence that the death induced by Col V-treatment is of the caspase-9 apoptotic type. We used (1) optical and electron microscopy, (2) quantitation of TUNEL-labeled cells and (3) analysis of the expression levels of Col V and selected genes coding for apoptosis-linked factors, by conventional RT-PCR. BALB/c mice were injected intraperitoneally with 1.5 g/kg body weight of urethane. After urethane injection, the animals received intranasal administration of 20 µg/20 µl of Col V every day during 2 months. We report here that Col V treatment was able to determine significant increase in Col V protein and gene expression and in the percentage of TUNEL-positive cells, to up-regulate caspase-9, resulting in low growth of tumor cells. Our data validate chemical carcinogenesis as a suitable "in vivo" model for further and more detailed studies on the molecular mechanisms of the death response induced by Col V in lung infiltrating adenocarcinoma opening new strategies for treatment.

No abstract

A study of the the fable of the Fox and the Ape (Aesop 38 Chambry, 81 Perry?) narrated inthe iambi of Archilochus. The commentary on the fragments (Arch. 185-187W) discusses their ancientsources, textual difficulties, and the modern reconstructions of Archilochus’ “ainos” via Aesop andBabrius (a). The “ethos” of the fox and of the ape in antiquity, examined in section b), illuminates themanner in which the poet attacks his enemy in this iambus.

(1947, p. 102-103) 3 sugeriram que a descrição do sujeito nestes versos pode ter sido influenciada pelas kórai da estatuária arcaica. Palavras-chave: Arquíloco; Poesia Grega Arcaica; Jambos; Heteras Abstract: This paper presents comments on fragments 30, 31, and 33 IEG of Archilochus, and their critical fortune. Fragments 30 and 31 IEG were united in a single poem by Bergk (1882Bergk ( , 1915, in which he was followed by many editors and critics. This joining of the fragments will be discussed, as well as the images that gave rise to different, and sometimes entirely opposite, interpretations: some read the verses "romantically" as a moving description of the young Neoboule, the poet's "fiancée"; while others, since Liebel (1812Liebel ( , 1818, suppose the myrtle and rose (Fr. 30