Background: Professionals who care for patients with advanced chronic nononcological disease need accurate prognostic tools. There are validated prognostic indices for nononcological pathology in the fields of internal medicine (PALIAR and PROFUND indices) and palliative care (PPI indices, PaP score, ECOG, PPS, KI). The objective of this study is to describe survival and analyzsed factors associated with mortality in advanced chronic nononcological disease patients in palliative care services in the Community of Madrid.Methods: Multilongitudinal observational study of a prospective cohort with a 6-month follow-up. Sociodemographic, clinical, analytical, service use, functionality, and prognostic indices were measured. Survival was analysed at 3 and 6 weeks and at 1, 2, 3, 4, 5, and 6 months through Kaplan–Meier curves. After the bivariate analysis, a Cox proportional-hazards multivariate regression analysis was performed. Results: 217 patients were included. The mean age (SD) was 78.8 (12.6), and 47.5% were women. Some 129 patients died. Mean survival (SD) at 6 months was 146.12 (130.14) days, median (IQR) survival 111.5 (17.50-254.50). All prognostic indices (PALIAR p<0.001, PROFUND p<0.005, PPI p<0.016, PaP Score p<0.001, ECOG p<0.002, PPS p<0.018, and KI p<0.016) predicted mortality at 6 months. The variables that explained survival at less than 3 months were PPS (HR (CI) 0.96 (0.95-0.98), p<0.000), leukocytes (HR (CI) 1.06 (1.02-1.10), p<0.000), delirium at the last admission (HR (CI) 1.79 (1.02-3.09) p<0.030), and ≥4 hospitalization in the last year (HR (CI) 1.82 (1.16-2.88) p<0.010). The variables that explained 6-month survival were PPS (HR (CI) 0.96 (0.94-0.97), p<0.000), leukocytes (HR (CI) 1.06 (1.03-1.09), p<0.000), and haemoglobin (HR (CI) 0.88 (0.82-0.97) p<0.005).Conclusions: Clinical and resource use variables were predictors of mortality in survivals shorter than 3 months, but not in survivals longer than 3 months.